Org 12,962

Org 12,962
(IUPAC) ime
	1-(5-trifluorometil-6-hloropiridin-2-il)piperazin
Klinički podaci
Identifikatori
CAS broj	210821-63-9
ATC kod	nije dodeljen
PubChem	9796408
ChemSpider	7972174
ChEMBL	CHEMBL506999
Hemijski podaci
Formula	C10H11ClF3N3
Mol. masa	265,662 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2 ; Key: QZYYPQAYSFBKPW-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisana supstanca

Org 12,962 je lek koji deluje kao potentan i selektivan agonist za 5-HT₂ receptorske familije, sa visokim afinitetom za 5-HT_2C i nižim za 5-HT_2B tip.^[5] On je razvijen kao potencijalni lek protiv anksioznosti, ali su klinička ispitivanja prekinuta nakon što su testovi pokazali da je njegov dejstvo praćeno nuspojavama kao što je vrtoglavica, što se objašnjava nedovoljnom selektivnošću in vivo u odnosu na halucinogeni 5-HT_2A receptor.^[6]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ (September 1999). „Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells”. British Journal of Pharmacology 128 (1): 13–20. DOI:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.
↑ Monck NJ, Kennett GA (2008). „5-HT2C ligands: recent progress”. Progress in Medicinal Chemistry 46: 281–390. DOI:10.1016/S0079-6468(07)00006-9. PMID 18381128.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid10498829-5] Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ (September 1999). „Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells”. British Journal of Pharmacology 128 (1): 13–20. DOI:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.

[pmid18381128-6] Monck NJ, Kennett GA (2008). „5-HT2C ligands: recent progress”. Progress in Medicinal Chemistry 46: 281–390. DOI:10.1016/S0079-6468(07)00006-9. PMID 18381128.

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Org 12,962

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