SB-269,970
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(IUPAC) ime | |||
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(2R)-1-[(3-Hidroksifenil)sulfonil]-2 -(2-(4-metil-1-piperidinil)etil)pirolidin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 201038-74-6 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 6604889 | ||
ChEMBL[3] | CHEMBL282199 ![]() | ||
Hemijski podaci | |||
Formula | C18H28N2O3S | ||
Mol. masa | 352,490 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
SB-269,970 je lek i istraživačka hemikalija. Ranije se smatralo da deluje kao selektivni antagonist (or inverzni agonist) 5-HT7 receptora, ali su naknadna istraživanja pokazala da on takođe potencijalno blokira α2-adrenergički receptor.[4][5][6]
Reference[uredi - уреди | uredi kôd]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Mahé C, Loetscher E, Feuerbach D, Müller W, Seiler MP, Schoeffter P (2004). „Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors”. Eur. J. Pharmacol. 495 (2–3): 97–102. DOI:10.1016/j.ejphar.2004.05.033. PMID 15249157.
- ↑ Lovell PJ, Bromidge SM, Dabbs S, et al. (2000). „A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)”. J. Med. Chem. 43 (3): 342–5. DOI:10.1021/jm991151j. PMID 10669560.
- ↑ Foong JP, Bornstein JC. (2009). „5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig”. Neuroreport. 20 (3): 325–330. DOI:10.1097/WNR.0b013e3283232caa. PMID 19190523.
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