SB-269,970

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SB-269,970
(IUPAC) ime
(2R)-1-[(3-Hidroksifenil)sulfonil]-2 -(2-(4-metil-1-piperidinil)etil)pirolidin
Klinički podaci
Identifikatori
CAS broj 201038-74-6
ATC kod nije dodeljen
PubChem[1][2] 6604889
ChEMBL[3] CHEMBL282199 YesY
Hemijski podaci
Formula C18H28N2O3S 
Mol. masa 352,490 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

SB-269,970 je lek i istraživačka hemikalija. Ranije se smatralo da deluje kao selektivni antagonist (or inverzni agonist) 5-HT7 receptora, ali su naknadna istraživanja pokazala da on takođe potencijalno blokira α2-adrenergički receptor.[4][5][6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Mahé C, Loetscher E, Feuerbach D, Müller W, Seiler MP, Schoeffter P (2004). "Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors". Eur. J. Pharmacol. 495 (2–3): 97–102. PMID 15249157. doi:10.1016/j.ejphar.2004.05.033. 
  5. Lovell PJ, Bromidge SM, Dabbs S et al. (2000). "A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)". J. Med. Chem. 43 (3): 342–5. PMID 10669560. doi:10.1021/jm991151j. 
  6. Foong JP, Bornstein JC. (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig". Neuroreport. 20 (3): 325–330. PMID 19190523. doi:10.1097/WNR.0b013e3283232caa. 

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