SB-269,970

SB-269,970
(IUPAC) ime
	(2R)-1-[(3-Hidroksifenil)sulfonil]-2 -(2-(4-metil-1-piperidinil)etil)pirolidin
Klinički podaci
Identifikatori
CAS broj	201038-74-6
ATC kod	nije dodeljen
PubChem	6604889
ChEMBL	CHEMBL282199
Hemijski podaci
Formula	C18H28N2O3S
Mol. masa	352,490 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3 ; Key: HWKROQUZSKPIKQ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-269,970 je lek i istraživačka hemikalija. Ranije se smatralo da deluje kao selektivni antagonist (or inverzni agonist) 5-HT₇ receptora, ali su naknadna istraživanja pokazala da on takođe potencijalno blokira α₂-adrenergički receptor.^[4]^[5]^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Mahé C, Loetscher E, Feuerbach D, Müller W, Seiler MP, Schoeffter P (2004). „Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors”. Eur. J. Pharmacol. 495 (2–3): 97–102. DOI:10.1016/j.ejphar.2004.05.033. PMID 15249157.
↑ Lovell PJ, Bromidge SM, Dabbs S, et al. (2000). „A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)”. J. Med. Chem. 43 (3): 342–5. DOI:10.1021/jm991151j. PMID 10669560.
↑ Foong JP, Bornstein JC. (2009). „5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig”. Neuroreport. 20 (3): 325–330. DOI:10.1097/WNR.0b013e3283232caa. PMID 19190523.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid15249157-4] Mahé C, Loetscher E, Feuerbach D, Müller W, Seiler MP, Schoeffter P (2004). „Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors”. Eur. J. Pharmacol. 495 (2–3): 97–102. DOI:10.1016/j.ejphar.2004.05.033. PMID 15249157.

[pmid10669560-5] Lovell PJ, Bromidge SM, Dabbs S, et al. (2000). „A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)”. J. Med. Chem. 43 (3): 342–5. DOI:10.1021/jm991151j. PMID 10669560.

[pmid19190523-6] Foong JP, Bornstein JC. (2009). „5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig”. Neuroreport. 20 (3): 325–330. DOI:10.1097/WNR.0b013e3283232caa. PMID 19190523.

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