Lekozotan

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Lekozotan
(IUPAC) ime
4-Cijano-N-[(2R)-2-[4-(2,3-dihidro-1,4-benzodioksin-5-il)-1-piperazinil]propil]-N-2-piridinilbenzamid hidrohlorid
Klinički podaci
Identifikatori
CAS broj 434283-16-6
ATC kod nije dodeljen
PubChem[1][2] 11156648
UNII 48854OTZ5E YesY
KEGG[3] D04683 YesY
Hemijski podaci
Formula C28H30ClN5O3 
Mol. masa 520,021 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Lekozotan potencijalni lek za poboljšanje kognitivnih funkcija kod obolelih od Alchajmerove bolesti.[4][5]

Metod dejstva[uredi - уреди | uredi kôd]

Lekozotan je kompetitivni, selektivni antagonist 5-HT1A receptor[6] koji povišava kalijumom stimulisano otpuštanje acetilholina i glutamata.[7]

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  4. H. Spreitzer (2008-08-13). „Neue Wirkstoffe - Lecozotan” (German). Österreichische Apothekerzeitung (17/2007): 805. 
  5. ClinicalTrials
  6. Schlechter, LE; Smith, DL; Rosenzweig-Lipson, S; Sukoff, SJ; Dawson, LA; Marquis, K; Jones, D; Piesla, M i dr.. (2005-06-10). „Lecotozan (SRA-333): A selective serotonin1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and promotes procognitive effects”. Journal of Pharmacology and Experimental Therapeutics 314 (3): 1274. DOI:10.1124/jpet.105.086363. PMID 15951399. http://jpet.aspetjournals.org/cgi/content/short/jpet.105.086363v1. 
  7. Childers, WE Jr, Harrison, BL, Abou-Gharbia, MA, Raje, S, Parks, V, Pangalos, MN, Schechter, LE (2007). „Lecozotan Hydrochloride”. Drugs of the Future 32 (5): 399–407. DOI:10.1358/dof.2007.032.05.1092901. http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=1092901&p_IsPs=N. 

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