ICI-118,551

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ICI-118,551
ICI 118551.svg
IUPAC ime
Identifikacija
CAS registarski broj 72795-19-8 YesY
PubChem[1][2] 3682
MeSH ICI+118551
ChEMBL[3] CHEMBL513389 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C17H27NO2
Molarna masa 277,402 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

ICI-118,551 je selektivni antagonist beta-22) adrenergičkog receptora.[4][5] ICI se vezuje za β2 receptor sa više od sto puta većim afinitetom nego za β1 ili β3 receptor.[6][7] Kompanija Imperijalne hemijske industrije je razvila ovo jedinjenje.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus". The Journal of Pharmacology and Experimental Therapeutics 314 (2): 561–7. PMID 15908513. doi:10.1124/jpet.105.084947. 
  5. Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). "A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors". Journal of Pharmacological and Toxicological Methods 58 (3): 189–97. PMID 18652905. doi:10.1016/j.vascn.2008.06.003. 
  6. Mauriège P, De Pergola G, Berlan M, Lafontan M (May 1988). "Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists". Journal of Lipid Research 29 (5): 587–601. PMID 2900871. 
  7. Emorine LJ, Marullo S, Briend-Sutren MM et al. (September 1989). "Molecular characterization of the human beta 3-adrenergic receptor". Science 245 (4922): 1118–21. PMID 2570461. doi:10.1126/science.2570461. 

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