2-Metil-5-hidroksitriptamin

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2-Metil-5-hidroksitriptamin
(IUPAC) ime
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
Klinički podaci
Identifikatori
CAS broj 78263-90-8
ATC kod ?
PubChem[1][2] 1574
ChemSpider[3] 1518
KEGG[4] C13665 YesY
ChEMBL[5] CHEMBL266591 YesY
Hemijski podaci
Formula C11H14N2O 
Mol. masa 190.242 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

2-Metil-5-hidroksitriptamin (2-Metilserotonin, 2-Metil-5-HT) je triptaminski derivat koji je blisko srodan neurotransmiteru serotonin. On deluje kao umereno selektivan agonist 5-HT3 receptora.[6][7][8]

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Literatura[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Elz S, Zimmermann H, Rehse K. (1993). "Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines.". Arch Pharm (Weinheim). 326 (11): 893–899. PMID 8274071. doi:10.1002/ardp.19933261110. 
  7. Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE. (1990). "5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.". Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9–16. PMID 2402303. 
  8. Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000.). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. http://www.acnp.org/g4/GN401000039/Ch039.html. pristupljeno 11. 04. 2008.. 


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