4-MeO-DMT

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4-MeO-DMT
(IUPAC) ime
2-(4-metoksi-1H-indol-3-il)-N,N-dimetiletanamin
Klinički podaci
Identifikatori
CAS broj 3965-97-7
ATC kod nije dodeljen
PubChem[1][2] 12017578
ChemSpider[3] 23126449
ChEMBL[4] CHEMBL32029 YesY
Hemijski podaci
Formula C13H18N2O 
Mol. masa 218,29 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

4-Metoksi-N,N-dimetiltriptamin (4-MeO-DMT), je triptaminski derivat koji deluje u životinjskim modelima na sličan način sa srodnim halucinogenim triptaminskim lekovima, mada sa znatno nižom potencijom od 5-MeO-DMT i 4-hidroksi-DMT (psilocina).[5][6][7][8] Homolog dužeg lanca 4-MeO-DET nije aktivan kod ljudi u dozama do 30 mg oralno ili pušenjem. Klinička ispitivanja su pokazala da je njegov izomer 4-MeO-MiPT aktivan u maloj meri.[9]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Glennon RA, Young R, Benington F, Morin RD (February 1982). "Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts". Life Sciences 30 (5): 465–7. PMID 6801410. doi:10.1016/0024-3205(82)90463-5. 
  6. Kline TB, Benington F, Morin RD, Beaton JM (August 1982). "Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety". Journal of Medicinal Chemistry 25 (8): 908–13. PMID 7120280. doi:10.1021/jm00350a005. 
  7. Kline TB, Benington F, Morin RD, Beaton JM, Glennon RA, Domelsmith LN, Houk KN, Rozeboom MD (November 1982). "Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives". Journal of Medicinal Chemistry 25 (11): 1381–3. PMID 6815326. doi:10.1021/jm00353a021. 
  8. Nichols DE, Glennon RA. Medicinal Chemistry and Structure-Activity Relationships of Hallucinogens, in Hallucinogens, Neurochemical, Behavioral, and Clinical Perspectives (Raven Press 1984), pp 95-142. ISBN 978-0-89004-990-7
  9. 4-MeO-MiPT Entry in TIHKAL