5-(Noniloksi)triptamin

5-(Noniloksi)triptamin
(IUPAC) ime
	2-(5-noniloksi-1H-indol-3-il)etanamin
Klinički podaci
Identifikatori
CAS broj	157798-12-4
ATC kod	nije dodeljen
PubChem	1797
Hemijski podaci
Formula	C19H30N2O
Mol. masa	302,453 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H30N2O/c1-2-3-4-5-6-7-8-13-22-17-9-10-19-18(14-17)16(11-12-20)15-21-19/h9-10,14-15,21H,2-8,11-13,20H2,1H3 ; Key: YHSMSRREJYOGQJ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

5-(Noniloksi)triptamin je derivat triptamina koji deluje kao selektivni agonist 5-HT_1D serotoninskog receptora. Povećanje dužine O-alkoksi lanca u ovoj seriji generalno povećava potentnost i selektivnost za 5-HT_1D. Najveću aktivnost je utvrđeno da ima noniloksi derivat, koji ima 5-HT_1D afinitet vezivanja od 1.0 nM, i koji je oko 300x selektivniji nego za srodni 5-HT_1A receptor.^[3]^[4]

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↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (September 1994). „5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist”. Journal of Medicinal Chemistry 37 (18): 2828–30. DOI:10.1021/jm00044a001. PMID 8071931.
↑ Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (January 1996). „Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors”. Journal of Medicinal Chemistry 39 (1): 314–22. DOI:10.1021/jm950498t. PMID 8568822.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid8071931-3] Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (September 1994). „5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist”. Journal of Medicinal Chemistry 37 (18): 2828–30. DOI:10.1021/jm00044a001. PMID 8071931.

[pmid8568822-4] Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (January 1996). „Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors”. Journal of Medicinal Chemistry 39 (1): 314–22. DOI:10.1021/jm950498t. PMID 8568822.

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5-(Noniloksi)triptamin

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