5-HT1B receptor

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5-hidroksitriptaminski (serotoninski) receptor 1B
Identifikatori
SimboliHTR1B; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
Vanjski IDOMIM182131 MGI96274 HomoloGene669 IUPHAR: 5-HT1B GeneCards: HTR1B Gene
Pregled RNK izražavanja
PBB GE HTR1B 210799 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez335115551
EnsemblENSG00000135312ENSMUSG00000049511
UniProtP28222Q0VES5
RefSeq (mRNA)NM_000863NM_010482
RefSeq (protein)NP_000854NP_034612
Lokacija (UCSC)Chr 6:
78.23 - 78.23 Mb
Chr 9:
81.43 - 81.43 Mb
PubMed pretraga[1][2]

5-HT1B receptor (5-hidroksitriptaminski receptor 1B) je protein koji je kod ljudi kodiran HTR1B genom.[1][2] 5-HT1B receptor je tip 5-HT receptora.[3]

Distribucija u tkivu i funkcija[uredi - уреди | uredi kôd]

5-HT1B receptor deluje na CNS, gde indukuje presinaptičku inhibiciju i utiče na ponašanje. On takođe ima vaskularne efekte, kao što je pulmonarna vazokonstrikcija.

Blokiranje 5-HT1B receptora povećava broj osteoblasta, koštanu masu, i brzinu formiranja kostiju.[4]

Ligandi[uredi - уреди | uredi kôd]

Agonisti

Antagonisti i inverzni agonisti

Genetika[uredi - уреди | uredi kôd]

Ovaj protein je kod ljudi kodiran HTR1B genom.

Genetička varijanta u promotorskom regionu, A-161T, je bila ispitana u pogledu inpakta na crte ličnosti, i utvrđeno je da nema uticaja.[8]

Vidi još[uredi - уреди | uredi kôd]

Reference[uredi - уреди | uredi kôd]

  1. Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF (March 1992). „Characterization of the human 5-hydroxytryptamine1B receptor”. J. Biol. Chem. 267 (9): 5735–8. PMID 1348246. 
  2. Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV (February 2001). „Genetic diversity of the human serotonin receptor 1B (HTR1B) gene”. Genomics 72 (1): 1–14. DOI:10.1006/geno.2000.6411. PMID 11247661. 
  3. „Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B”. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351. 
  4. Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G (November 2008). „Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum”. Cell 135 (5): 825–37. DOI:10.1016/j.cell.2008.09.059. PMC 2614332. PMID 19041748. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2614332/. Lay summary – medpagetoday.com. 
  5. Hudzik, TJ; Yanek, M; Porrey, T; Evenden, J; Paronis, C; Mastrangelo, M; Ryan, C; Ross, S i dr.. (2003). „Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist.”. The Journal of pharmacology and experimental therapeutics 304 (3): 1072–84. DOI:10.1124/jpet.102.045468. PMID 12604684. 
  6. Selkirk, JV; Scott, C; Ho, M; Burton, MJ; Watson, J; Gaster, LM; Collin, L; Jones, BJ i dr.. (1998). „SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.”. British journal of pharmacology 125 (1): 202–8. DOI:10.1038/sj.bjp.0702059. PMC 1565605. PMID 9776361. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1565605/. 
  7. Roberts, C; Watson, J; Price, GW; Middlemiss, DN (2001). „SB-236057-A: a selective 5-HT1B receptor inverse agonist.”. CNS drug reviews 7 (4): 433–44. PMID 11830759. 
  8. Tsai SJ, Wang YC, Chen JY, Hong CJ (2003). „Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits”. Neuropsychobiology 48 (2): 68–71. DOI:10.1159/000072879. PMID 14504413. 

Literatura[uredi - уреди | uredi kôd]

Spoljašnje veze[uredi - уреди | uredi kôd]