Niacinski receptor 2

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Niacinskit receptor 2
Identifikatori
Simboli NIACR2; GPR109B; HM74; PUMAG; Puma-g
Vanjski ID OMIM606039 HomoloGene55944 IUPHAR: GeneCards: NIACR2 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 8843 n/a
Ensembl ENSG00000182782 n/a
UniProt P49019 n/a
RefSeq (mRNA) NP_006009 n/a
RefSeq (protein) NM_006018 n/a
Lokacija (UCSC) Chr 12:
121.77 - 121.77 Mb
n/a
PubMed pretraga [1] n/a

Niacinski receptor 2, NIACR2 ili GPR109B, je protein koji je kod čoveka kodiran NIACR2 genom.[1][2]

Funkcija[uredi - уреди | uredi izvor]

GPR109B ima nizak afinitet za nikotinsku kiselinu (niacin)[3] pripada grupi GPCR receptora nikotinske kiseline (drugi pripadnik grupe je GPR109A).

GPR109B je Gi/Go protein-spregnuti receptor.[3]

Literatura[uredi - уреди | uredi izvor]

  1. "Entrez Gene: GPR109B G protein-coupled receptor 109B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8843. 
  2. Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. PMID 7505609. doi:10.1093/intimm/5.10.1239. 
  3. 3,0 3,1 Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry 278 (11): 9869–74. PMID 12522134. doi:10.1074/jbc.M210695200. 

Dodatna literatura[uredi - уреди | uredi izvor]

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