LPHN2

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Latrofilin 2
Identifikatori
Simboli LPHN2; CIRL2; CL2; LEC1; LPHH1
Vanjski ID OMIM607018 MGI2139714 HomoloGene22712 IUPHAR: LPHN2 GeneCards: LPHN2 Gene
Pregled RNK izražavanja
PBB GE LPHN2 206953 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 23266 99633
Ensembl ENSG00000117114 ENSMUSG00000028184
UniProt O95490 Q8JZZ7
RefSeq (mRNA) NM_012302.2 NM_001081298.1
RefSeq (protein) NP_036434.1 NP_001074767.1
Lokacija (UCSC) Chr 1:
81.77 - 82.46 Mb
Chr 3:
148.48 - 148.65 Mb
PubMed pretraga [1] [2]

Latrofilin-2 je protein koji je kod ljudi kodrian LPHN2 genom.[1][2]

Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Dok je nekoliko transkriptnih varijanti poznato, do sada je samo jedna biološki okarakterisana.[2]

Reference[uredi - уреди]

  1. White GR, Varley JM, Heighway J (Jul 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochim Biophys Acta 1491 (1-3): 75–92. PMID 10760572. 
  2. 2.0 2.1 "Entrez Gene: LPHN2 latrophilin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23266. 

Literatura[uredi - уреди]

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.". Annu. Rev. Neurosci. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923. 
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.". Toxicon 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  • White GR, Varley JM, Heighway J (1999). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.". Oncogene 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676. 
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. 
  • Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Clark TA, Schweitzer AC, Chen TX et al. (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays.". Genome Biol. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239. 

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