LPHN2

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Latrofilin 2
Identifikatori
Simboli LPHN2; CIRL2; CL2; LEC1; LPHH1
Vanjski ID OMIM607018 MGI2139714 HomoloGene22712 IUPHAR: LPHN2 GeneCards: LPHN2 Gene
Pregled RNK izražavanja
PBB GE LPHN2 206953 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 23266 99633
Ensembl ENSG00000117114 ENSMUSG00000028184
UniProt O95490 Q8JZZ7
RefSeq (mRNA) NM_012302.2 NM_001081298.1
RefSeq (protein) NP_036434.1 NP_001074767.1
Lokacija (UCSC) Chr 1:
81.77 - 82.46 Mb
Chr 3:
148.48 - 148.65 Mb
PubMed pretraga [1] [2]

Latrofilin-2 je protein koji je kod ljudi kodrian LPHN2 genom.[1][2]

Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Dok je nekoliko transkriptnih varijanti poznato, do sada je samo jedna biološki okarakterisana.[2]

Reference[uredi - уреди]

  1. White GR, Varley JM, Heighway J (Jul 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochim Biophys Acta 1491 (1-3): 75–92. PMID 10760572. 
  2. 2.0 2.1 "Entrez Gene: LPHN2 latrophilin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23266. 

Literatura[uredi - уреди]

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.". Annu. Rev. Neurosci. 24 (1): 933–62. DOI:10.1146/annurev.neuro.24.1.933. PMID 11520923. 
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.". Toxicon 43 (5): 527–42. DOI:10.1016/j.toxicon.2004.02.008. PMID 15066411. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452. 
  • White GR, Varley JM, Heighway J (1999). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.". Oncogene 17 (26): 3513–9. DOI:10.1038/sj.onc.1202487. PMID 10030676. 
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. DOI:10.1074/jbc.C000490200. PMID 10964907. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414. 
  • Clark TA, Schweitzer AC, Chen TX, et al. (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays.". Genome Biol. 8 (4): R64. DOI:10.1186/gb-2007-8-4-r64. PMID 17456239. 

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