GPR81

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G protein-spregnuti receptor 81
Identifikatori
SimboliGPR81; FKSG80; GPR104; TA-GPCR
Vanjski IDOMIM606923 MGI2441671 HomoloGene13060 IUPHAR: GPR81 (temporary name) GeneCards: GPR81 Gene
Pregled RNK izražavanja
PBB GE GPR81 gnf1h00809 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez27198243270
EnsemblENSG00000196917ENSMUSG00000049241
UniProtQ9BXC0Q8C131
RefSeq (mRNA)NM_032554NM_175520
RefSeq (protein)NP_115943NP_780729
Lokacija (UCSC)Chr 12:
121.78 - 121.78 Mb
Chr 5:
124.14 - 124.14 Mb
PubMed pretraga[1][2]

G protein-spregnuti receptor 81, ili GPR81, je protein koji je kod čoveka kodiran GPR81 genom.[1][2]

G protein spregnuti receptori poput GPR81, sadrže 7 transmembranskih domena i prenose ekstracelularne signale putem heterotrimernih G proteina.[1]

Laktat aktivira GPR81 receptor, koji zatim inhibira lipolizu u ćelijama masnog tkiva.[3][4]

Literatura[uredi - уреди | uredi izvor]

  1. 1,0 1,1 "Entrez Gene: GPR81 G protein-coupled receptor 81". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27198. 
  2. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5. 
  3. Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW (January 2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". J. Biol. Chem. 284 (5): 2811–22. PMID 19047060. doi:10.1074/jbc.M806409200. 
  4. Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG (December 2008). "Role of GPR81 in lactate-mediated reduction of adipose lipolysis". Biochem. Biophys. Res. Commun. 377 (3): 987–91. PMID 18952058. doi:10.1016/j.bbrc.2008.10.088. 

Dodatna literatura[uredi - уреди | uredi izvor]