RAIG
(Preusmjereno sa stranice Retinoinska kiselina-indukujući orfan G protein-spregnuti receptor)
| G protein spregnuti receptor, familija C, grupa 5, član A | |
|---|---|
| Identifikatori | |
| Simbol | GPRC5A |
| Alt. simboli | RAIG1, RAI3 |
| Entrez | 9052 |
| HUGO | 9836 |
| OMIM | 604138 |
| RefSeq | NM_003979 |
| UniProt | Q8NFJ5 |
| Drugi podaci | |
| Lokus | Hromozom 12 p13-p12.3 |
| G protein spregnuti receptor, familija C, grupa 5, član B | |
|---|---|
| Identifikatori | |
| Simbol | GPRC5B |
| Alt. simboli | RAIG2 |
| Entrez | 51704 |
| Hugo | 13308 |
| OMIM | 605948 |
| RefSek | NM_016235 |
| UniProt | Q9NZH0 |
| Drugi podaci | |
| Lokus | Hrom. 16 p12 |
| G protein spregnuti receptor, familija C, grupa 5, član C | |
|---|---|
| Identifikatori | |
| Simbol | GPRC5C |
| Alt. simboli | RAIG3 |
| Entrez | 55890 |
| Hugo | 13309 |
| OMIM | 605949 |
| RefSek | NM_022036 |
| UniProt | Q9NQ84 |
| Drugi podaci | |
| Lokus | Hrom. 17 q25 |
| G protein spregnuti receptor, familija C, grupa 5, član D | |
|---|---|
| Identifikatori | |
| Simbol | GPRC5D |
| Entrez | 55507 |
| Hugo | 13310 |
| OMIM | 607437 |
| RefSek | NM_018654 |
| UniProt | Q9NZD1 |
| Drugi podaci | |
| Lokus | Hrom. 12 p13.3 |
RAIG (Retinoinskom kiselinom inducibilni orfan G protein spregnuti receptori) su grupa od četiri blisko srodna G protein spregnuta receptora čije izražavanje je indukovano retinoinskom kiselinom.[1][2][3][4]
Funkcija ovih proteina nije određena. Pretpostavlja se da oni mogu da pruže mehanizam kojim retinoinska kiselina može da utiče na G proteinsku signalnu kaskadu. Osim toga, RAIG receptori formiraju interakcije sa članovima klase uvojitih G protein spregnutih receptora i potencijalno aktiviraju Wnt signalni put.[5]
Reference[uredi | uredi kod]
- ↑ Cheng Y, Lotan R (1998). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J. Biol. Chem. 273 (52): 35008–15. DOI:10.1074/jbc.273.52.35008. PMID 9857033.
- ↑ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics 65 (2): 121–8. DOI:10.1006/geno.2000.6164. PMID 10783259.
- ↑ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics 67 (1): 8–18. DOI:10.1006/geno.2000.6226. PMID 10945465.
- ↑ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”. Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.
- ↑ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). „Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling”. Biochem. Biophys. Res. Commun. 358 (4): 968–75. DOI:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.
Spoljašnje veze[uredi | uredi kod]
- „GPRC5 (RAIG) Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- MeSH GPRC5A+protein,+human
- MeSH GPRC5B+protein,+human
- MeSH GPRC5C+protein,+human