RAIG

G protein spregnuti receptor, familija C, grupa 5, član C
Identifikatori
Simbol	GPRC5C
Alt. simboli	RAIG3
Entrez	55890
Hugo	13309
OMIM	605949
RefSek	NM_022036
UniProt	Q9NQ84
Drugi podaci
Lokus	Hrom. 17 q25

G protein spregnuti receptor, familija C, grupa 5, član B
Identifikatori
Simbol	GPRC5B
Alt. simboli	RAIG2
Entrez	51704
Hugo	13308
OMIM	605948
RefSek	NM_016235
UniProt	Q9NZH0
Drugi podaci
Lokus	Hrom. 16 p12

G protein spregnuti receptor, familija C, grupa 5, član A
Identifikatori
Simbol	GPRC5A
Alt. simboli	RAIG1, RAI3
Entrez	9052
HUGO	9836
OMIM	604138
RefSeq	NM_003979
UniProt	Q8NFJ5
Drugi podaci
Lokus	Hromozom 12 p13-p12.3

G protein spregnuti receptor, familija C, grupa 5, član D
Identifikatori
Simbol	GPRC5D
Entrez	55507
Hugo	13310
OMIM	607437
RefSek	NM_018654
UniProt	Q9NZD1
Drugi podaci
Lokus	Hrom. 12 p13.3

RAIG (Retinoinskom kiselinom inducibilni orfan G protein spregnuti receptori) su grupa od četiri blisko srodna G protein spregnuta receptora čije izražavanje je indukovano retinoinskom kiselinom.^[1]^[2]^[3]^[4]

Funkcija ovih proteina nije određena. Pretpostavlja se da oni mogu da pruže mehanizam kojim retinoinska kiselina može da utiče na G proteinsku signalnu kaskadu. Osim toga, RAIG receptori formiraju interakcije sa članovima klase uvojitih G protein spregnutih receptora i potencijalno aktiviraju Wnt signalni put.^[5]

Reference

↑ Cheng Y, Lotan R (1998). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J. Biol. Chem. 273 (52): 35008–15. DOI:10.1074/jbc.273.52.35008. PMID 9857033.
↑ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics 65 (2): 121–8. DOI:10.1006/geno.2000.6164. PMID 10783259.
↑ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics 67 (1): 8–18. DOI:10.1006/geno.2000.6226. PMID 10945465.
↑ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”. Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.
↑ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). „Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling”. Biochem. Biophys. Res. Commun. 358 (4): 968–75. DOI:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

Vanjske veze

„GPRC5 (RAIG) Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH GPRC5A+protein,+human
MeSH GPRC5B+protein,+human
MeSH GPRC5C+protein,+human

[pmid9857033-1] Cheng Y, Lotan R (1998). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J. Biol. Chem. 273 (52): 35008–15. DOI:10.1074/jbc.273.52.35008. PMID 9857033.

[pmid10783259-2] Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics 65 (2): 121–8. DOI:10.1006/geno.2000.6164. PMID 10783259.

[pmid10945465-3] Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics 67 (1): 8–18. DOI:10.1006/geno.2000.6226. PMID 10945465.

[pmid11311935-4] Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”. Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.

[pmid17521608-5] Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). „Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling”. Biochem. Biophys. Res. Commun. 358 (4): 968–75. DOI:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

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