RXFP2

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Relaksinu/insulinu-slična familija, peptidni receptor 2
Identifikatori
SimboliRXFP2; GPR106; GREAT; INSL3R; LGR8; LGR8.1
Vanjski IDOMIM606655 MGI2153463 HomoloGene15402 IUPHAR: RXFP2 GeneCards: RXFP2 Gene
Ortolozi
VrstaČovekMiš
Entrez122042140498
EnsemblENSG00000133105ENSMUSG00000053368
UniProtQ8WXD0Q0VB90
RefSeq (mRNA)NM_130806NM_080468
RefSeq (protein)NP_570718NP_536716
Lokacija (UCSC)Chr 13:
31.21 - 31.28 Mb
Chr 5:
150.29 - 150.35 Mb
PubMed pretraga[1][2]

RXFP2, relaksinu/insulinu-slična familija, peptidni receptor 2, je humani G-protein spregnuti receptor.[1]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Bathgate RA, Ivell R, Sanborn BM et al. (2005). "Receptors for relaxin family peptides.". Ann. N. Y. Acad. Sci. 1041: 61–76. PMID 15956688. doi:10.1196/annals.1282.010. 
  • Bathgate RA, Ivell R, Sanborn BM et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.". Pharmacol. Rev. 58 (1): 7–31. PMID 16507880. doi:10.1124/pr.58.1.9. 
  • Hsu SY, Nakabayashi K, Nishi S et al. (2002). "Activation of orphan receptors by the hormone relaxin.". Science 295 (5555): 671–4. PMID 11809971. doi:10.1126/science.1065654. 
  • Kumagai J, Hsu SY, Matsumi H et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.". J. Biol. Chem. 277 (35): 31283–6. PMID 12114498. doi:10.1074/jbc.C200398200. 
  • Gorlov IP, Kamat A, Bogatcheva NV et al. (2003). "Mutations of the GREAT gene cause cryptorchidism.". Hum. Mol. Genet. 11 (19): 2309–18. PMID 12217959. doi:10.1093/hmg/11.19.2309. 
  • Sudo S, Kumagai J, Nishi S et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.". J. Biol. Chem. 278 (10): 7855–62. PMID 12506116. doi:10.1074/jbc.M212457200. 
  • Ferlin A, Simonato M, Bartoloni L et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.". J. Clin. Endocrinol. Metab. 88 (9): 4273–9. PMID 12970298. doi:10.1210/jc.2003-030359. 
  • Roh J, Virtanen H, Kumagai J et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism.". Reprod. Biomed. Online 7 (4): 400–6. PMID 14656401. doi:10.1016/S1472-6483(10)61883-4. 
  • Vinci G, Anjot MN, Trivin C et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia.". J. Clin. Endocrinol. Metab. 89 (12): 6282–5. PMID 15579790. doi:10.1210/jc.2004-0891. 
  • Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor.". J. Biol. Chem. 280 (15): 14586–90. PMID 15708846. doi:10.1074/jbc.M414443200. 
  • Muda M, He C, Martini PG et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.". Mol. Hum. Reprod. 11 (8): 591–600. PMID 16051677. doi:10.1093/molehr/gah205. 
  • Rosengren KJ, Zhang S, Lin F et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.". J. Biol. Chem. 281 (38): 28287–95. PMID 16867980. doi:10.1074/jbc.M603829200. 
  • Bogatcheva NV, Ferlin A, Feng S et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.". Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. PMID 16926383. doi:10.1152/ajpendo.00228.2006. 
  • Scott DJ, Layfield S, Yan Y et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.". J. Biol. Chem. 281 (46): 34942–54. PMID 16963451. doi:10.1074/jbc.M602728200. 
  • El Houate B, Rouba H, Sibai H et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism.". J. Urol. 177 (5): 1947–51. PMID 17437853. doi:10.1016/j.juro.2007.01.002. 
  • Scott DJ, Wilkinson TN, Zhang S et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3.". Mol. Endocrinol. 21 (7): 1699–712. PMID 17473281. doi:10.1210/me.2007-0097. 

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