Kortikotropin-oslobađajući hormonski receptor 1

Iz Wikipedije, slobodne enciklopedije
edit
Kortikotropin-oslobađajući hormonski receptor 1
Identifikatori
Simboli CRHR1; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR1f
Vanjski ID OMIM122561 MGI88498 HomoloGene20920 IUPHAR: CRF1 GeneCards: CRHR1 Gene
Pregled RNK izražavanja
PBB GE CRHR1 214619 at tn.png
PBB GE CRHR1 208593 x at tn.png
PBB GE CRHR1 211897 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1394 12921
Ensembl ENSG00000120088 ENSMUSG00000018634
UniProt P34998 Q0VGH2
RefSeq (mRNA) XM_001128344 NM_007762
RefSeq (protein) XP_001128344 NP_031788
Lokacija (UCSC) Chr 17:
41.24 - 41.27 Mb
Chr 11:
103.95 - 103.99 Mb
PubMed pretraga [1] [2]

Kortikotropin-oslobađajući hormonski receptor 1 (CRHR1, CRF1) je protein koji je kod ljudi kodiran CRHR1 genom.[1][2][3]

Funkcija[uredi - уреди | uredi izvor]

Kortikotropin-oslobađajući hormonski receptor vezuje kortikotropin-oslobađajući hormon, potentan posrednik endokrinog, autonomnog, i imunskog responsa na stres.[4]

Kod miševa CRF1 receptori posreduju etanolno pojačanje GABAergične sinaptičke transmisije.[5]

Klinički značaj[uredi - уреди | uredi izvor]

Varijacije CRHR1 gena su povezane za povećanjem odgovora na inhalacionu kortikosteroidnu terapiju kod astme.[6] Antagonisti CRF1 receptora se aktivno ispituju kao mogući tretman za depresiju i anksioznost.[7][8]

Interakcije[uredi - уреди | uredi izvor]

Za kortikotropin-oslobađajući hormonski receptor 1 je pokazano da interaguje sa kortikotropin-oslobađajućim hormonom[9][10] i urokortinom.[11][10]

Vidi još[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  1. Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (March 2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. PMID 12615952. doi:10.1124/pr.55.1.3. 
  2. Polymeropoulos MH, Torres R, Yanovski JA, Chandrasekharappa SC, Ledbetter DH (July 1995). "The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22". Genomics 28 (1): 123–4. PMID 7590738. doi:10.1006/geno.1995.1118. 
  3. Chen R, Lewis KA, Perrin MH, Vale WW (October 1993). "Expression cloning of a human corticotropin-releasing-factor receptor". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8967–71. PMC 47482. PMID 7692441. doi:10.1073/pnas.90.19.8967. 
  4. "Entrez Gene: CRHR1 corticotropin releasing hormone receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1394. 
  5. Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR (March 2004). "Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors". Science (journal) 303 (5663): 1512–4. PMID 15001778. doi:10.1126/science.1092550. 
  6. Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST (July 2004). "Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids". Hum. Mol. Genet. 13 (13): 1353–9. PMID 15128701. doi:10.1093/hmg/ddh149. 
  7. Kehne JH (June 2007). "The CRF1 receptor, a novel target for the treatment of depression, anxiety, and stress-related disorders". CNS Neurol Disord Drug Targets 6 (3): 163–82. PMID 17511614. doi:10.2174/187152707780619344. 
  8. Ising M, Holsboer F (December 2007). "CRH-sub-1 receptor antagonists for the treatment of depression and anxiety". Exp Clin Psychopharmacol 15 (6): 519–28. PMID 18179304. doi:10.1037/1064-1297.15.6.519. 
  9. Grammatopoulos, D K; Dai Y, Randeva H S, Levine M A, Karteris E, Easton A J, Hillhouse E W (December 1999). "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes". Mol. Endocrinol. (UNITED STATES) 13 (12): 2189–202. ISSN 0888-8809. PMID 10598591. doi:10.1210/me.13.12.2189. 
  10. 10,0 10,1 Gottowik, J; Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc R G, Moreau J L, Monsma F J, Kilpatrick G J (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology (ENGLAND) 36 (10): 1439–46. ISSN 0028-3908. PMID 9423932. doi:10.1016/S0028-3908(97)00098-1. 
  11. Donaldson, C J; Sutton S W, Perrin M H, Corrigan A Z, Lewis K A, Rivier J E, Vaughan J M, Vale W W (May 1996). "Cloning and characterization of human urocortin". Endocrinology (UNITED STATES) 137 (5): 2167–70. ISSN 0013-7227. PMID 8612563. doi:10.1210/en.137.5.2167. 

Dodatna literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]