P2RY14
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| Purinski receptor P2Y, G-protein spregnuti, 14 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | P2RY14; GPR105; KIAA0001; P2Y14 | ||||||||||
| Vanjski ID | OMIM: 610116 MGI: 2155705 HomoloGene: 15769 IUPHAR: P2Y14 GeneCards: P2RY14 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9934 | 140795 | |||||||||
| Ensembl | ENSG00000174944 | ENSMUSG00000036381 | |||||||||
| UniProt | Q15391 | Q544F4 | |||||||||
| RefSeq (mRNA) | NM_001081455 | NM_001008497 | |||||||||
| RefSeq (protein) | NP_001074924 | NP_001008497 | |||||||||
| Lokacija (UCSC) | Chr 3: 152.41 - 152.48 Mb | Chr 3: 59.2 - 59.22 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
P2Y purinoceptor 14 je protein koji je kod ljudi kodiran P2RY14 genom.[1]
Proizvod P2RY14 gena pripada familiji G-protein spregnutih receptora. Postoji nekoliko tipova receptora sa različitom farmakološkom selektivnošću za razne adenozinske i uridinske nukleotide. Ovaj receptor je P2Y purinski receptor za UDP-glukozu i druge UDP-šećere spregnute sa G-proteinima. Smatra se da on učestvuje u dejstvu imunskog sistema putem regulacije matičnih ćelija, kao i u neuroimunskim funkcijama. Dve transkriptne varijante koje kodiraju isti protein su poznate.[1]
Vidi još[uredi | uredi kod]
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Gerard C, Gerard NP (1994). „C5A anaphylatoxin and its seven transmembrane-segment receptor.”. Annu. Rev. Immunol. 12: 775–808. DOI:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
- Müller CE (2003). „P2-pyrimidinergic receptors and their ligands.”. Curr. Pharm. Des. 8 (26): 2353–69. DOI:10.2174/1381612023392937. PMID 12369950.
- Abbracchio MP, Boeynaems JM, Barnard EA, et al. (2003). „Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.”. Trends Pharmacol. Sci. 24 (2): 52–5. DOI:10.1016/S0165-6147(02)00038-X. PMID 12559763.
- von Kügelgen I (2006). „Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.”. Pharmacol. Ther. 110 (3): 415–32. DOI:10.1016/j.pharmthera.2005.08.014. PMID 16257449.
- Brunschweiger A, Müller CE (2006). „P2 receptors activated by uracil nucleotides--an update.”. Curr. Med. Chem. 13 (3): 289–312. DOI:10.2174/092986706775476052. PMID 16475938.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.”. DNA Res. 1 (1): 27–35. DOI:10.1093/dnares/1.1.27. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).”. DNA Res. 1 (1): 47–56. DOI:10.1093/dnares/1.1.47. PMID 7584028.
- Charlton ME, Williams AS, Fogliano M, et al. (1997). „The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge.”. Brain Res. 764 (1-2): 141–8. DOI:10.1016/S0006-8993(97)00438-1. PMID 9295203.
- Joensuu T, Hämäläinen R, Lehesjoki AE, et al. (2000). „A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q.”. Genomics 63 (3): 409–16. DOI:10.1006/geno.1999.6096. PMID 10704288.
- Chambers JK, Macdonald LE, Sarau HM, et al. (2000). „A G protein-coupled receptor for UDP-glucose.”. J. Biol. Chem. 275 (15): 10767–71. DOI:10.1074/jbc.275.15.10767. PMID 10753868.
- Wittenberger T, Schaller HC, Hellebrand S (2001). „An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.”. J. Mol. Biol. 307 (3): 799–813. DOI:10.1006/jmbi.2001.4520. PMID 11273702.
- Joensuu T, Hämäläinen R, Yuan B, et al. (2001). „Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.”. Am. J. Hum. Genet. 69 (4): 673–84. DOI:10.1086/323610. PMC 1226054. PMID 11524702.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). „Release of cellular UDP-glucose as a potential extracellular signaling molecule.”. Mol. Pharmacol. 63 (5): 1190–7. DOI:10.1124/mol.63.5.1190. PMID 12695547.
- Lee BC, Cheng T, Adams GB, et al. (2003). „P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.”. Genes Dev. 17 (13): 1592–604. DOI:10.1101/gad.1071503. PMC 196132. PMID 12842911.
- Skelton L, Cooper M, Murphy M, Platt A (2003). „Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose.”. J. Immunol. 171 (4): 1941–9. PMID 12902497.
- Moore DJ, Murdock PR, Watson JM, et al. (2004). „GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.”. Brain Res. Mol. Brain Res. 118 (1-2): 10–23. DOI:10.1016/S0169-328X(03)00330-9. PMID 14559350.
Spoljašnje veze[uredi | uredi kod]
- „P2Y Receptors: P2Y14”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.