Bombezinu-sličan receptor 3

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Bombezinu-sličan receptor 3‎
Identifikatori
SimboliBRS3;
Vanjski IDOMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 GeneCards: BRS3 Gene
Pregled RNK izražavanja
PBB GE BRS3 207369 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez68012209
EnsemblENSG00000102239ENSMUSG00000031130
UniProtP32247O54798
RefSeq (mRNA)NM_001727NM_009766
RefSeq (protein)NP_001718NP_033896
Lokacija (UCSC)Chr X:
135.4 - 135.4 Mb
Chr X:
53.39 - 53.4 Mb
PubMed pretraga[1][2]

Bombezinu-sličan receptor 3 (BRS-3, BB3)[1] je protein koji je kod ljudi kodiran BRS3 genom.[2][3]

Funkcija[uredi - уреди | uredi izvor]

Kod sisara su bombezinu-slični peptidi široko rasprostranjeni u centralnom nervnom sistemu, kao i u gastrointenstinalnom traktu, gde oni modulišu kontrakcije glatkih mišića, eksokrine i endokrine procese, metabolizam, i ponašanje. Oni deluju putem vezivanja za G protein-spregnute receptore na ćelijskoj površni. Bombezinu-slični peptidni receptori su gastrin-oslobađajući peptidni receptor, neuromedinski B receptor, i bombezinu-sličan receptor-3.[3][4]

BB3 je G protein-spregnuti receptor,[5] koji ima nizak afinitet za prirodne bombezinu-srodne peptide. Njegov endogeni ligand visokog afiniteta nije poznat, te je ovaj receptor klasifikovan kao orfanski receptor.[2][6][7]

Literatura[uredi - уреди | uredi izvor]

  1. "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958. 
  2. 2,0 2,1 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. 
  3. 3,0 3,1 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1-2): 165–72. PMID 9262170. doi:10.1016/S0006-8993(97)00380-6. 
  4. "Entrez Gene: BRS3 bombesin-like receptor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680. 
  5. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. 
  6. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.". J. Biol. Chem. 272 (41): 26062–26071. PMID 9325344. doi:10.1074/jbc.272.41.26062. 
  7. Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.". Pharmacol. Rev. 60 (1): 1–42. PMC 2517428. PMID 18055507. doi:10.1124/pr.107.07108. 

Dodatna literatura[uredi - уреди | uredi izvor]

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