Bombezinu-sličan receptor 3

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Bombezinu-sličan receptor 3‎
Identifikatori
SimboliBRS3;
Vanjski IDOMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 GeneCards: BRS3 Gene
Pregled RNK izražavanja
PBB GE BRS3 207369 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez68012209
EnsemblENSG00000102239ENSMUSG00000031130
UniProtP32247O54798
RefSeq (mRNA)NM_001727NM_009766
RefSeq (protein)NP_001718NP_033896
Lokacija (UCSC)Chr X:
135.4 - 135.4 Mb
Chr X:
53.39 - 53.4 Mb
PubMed pretraga[1][2]

Bombezinu-sličan receptor 3 (BRS-3, BB3)[1] je protein koji je kod ljudi kodiran BRS3 genom.[2][3]

Funkcija[uredi | uredi kod]

Kod sisara su bombezinu-slični peptidi široko rasprostranjeni u centralnom nervnom sistemu, kao i u gastrointenstinalnom traktu, gde oni modulišu kontrakcije glatkih mišića, eksokrine i endokrine procese, metabolizam, i ponašanje. Oni deluju putem vezivanja za G protein-spregnute receptore na ćelijskoj površni. Bombezinu-slični peptidni receptori su gastrin-oslobađajući peptidni receptor, neuromedinski B receptor, i bombezinu-sličan receptor-3.[3][4]

BB3 je G protein-spregnuti receptor,[5] koji ima nizak afinitet za prirodne bombezinu-srodne peptide. Njegov endogeni ligand visokog afiniteta nije poznat, te je ovaj receptor klasifikovan kao orfanski receptor.[2][6][7]

Literatura[uredi | uredi kod]

  1. „Bombesin Receptors: BB3. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. 2,0 2,1 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. [mrtav link]
  3. 3,0 3,1 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). „Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse”. Brain Res. 762 (1-2): 165–72. DOI:10.1016/S0006-8993(97)00380-6. PMID 9262170. 
  4. „Entrez Gene: BRS3 bombesin-like receptor 3”. 
  5. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. Arhivirano iz originala na datum 2007-12-27. Pristupljeno 2014-05-08. 
  6. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). „Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.”. J. Biol. Chem. 272 (41): 26062–26071. DOI:10.1074/jbc.272.41.26062. PMID 9325344. 
  7. Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). „International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.”. Pharmacol. Rev. 60 (1): 1–42. DOI:10.1124/pr.107.07108. PMC 2517428. PMID 18055507. 

Dodatna literatura[uredi | uredi kod]

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