Alfa-1B adrenergički receptor

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Adrenergički alfa-1B receptor
Identifikatori
Simboli	ADRA1B; ADRA1; ALPHA1BAR
Vanjski ID	OMIM: 104220 MGI: 104774 HomoloGene: 55477 IUPHAR: α1B-adrenoceptor GeneCards: ADRA1B Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • adrenoceptorska aktivnost • aktivnost alfa 1 adrenergičkog receptora Celularna komponenta • integralno sa membranom • membrana Biološki proces • remodelovanje krvnih sudova • respons na amfetamin • vazokonstrikcija arterija tokom baroreceptorskog responsa na sniženje krvnog pritiska • pozitivna regulacija brzine srčanih kontrakcija epinefrin-norepinefrina • povećanja snage srčanih kontrakcija epinefrinom-norepinefrinom • prenos signala • signalni put G-protein spregnutog receptora • G-proteinska signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glasnikom • kaskada proteinskih kinaza • interćelijska signalizacija • razvoj multićelijskog organizma • razvoj srca odraslih osoba • lokomotorno ponašanje • ćelijska proliferacija • vizuelno učenje • ćelijski rast • rast organa • glukozna homeostaza • respons na morfin • negativna regulacija glikogenskog kataboličkog procesa • pozitivna regulacija glikogenskog kataboličkog procesa • ponašanje u odgovoru na kokain
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	147	11548
Ensembl	ENSG00000170214	ENSMUSG00000050541
UniProt	P35368	Q05D47
RefSeq (mRNA)	NM_000679	NM_007416
RefSeq (protein)	NP_000670	NP_031442
Lokacija (UCSC)	Chr 5: 159.28 - 159.33 Mb	Chr 11: 43.62 - 43.74 Mb
PubMed pretraga	[1]	[2]

Alfa-1B adrenergički receptor (α_1B adrenoreceptor, ADRA1B), je alfa-1 adrenergički receptor, kodiran ADRA1B humanim genom.

Receptor

Postoje 3 tipa alfa-1 adrenergičkog receptora: alfa-1A, -1B i -1D. Svi oni prenose signal kroz Gq/11 familiju G-proteina. Različiti tipovi pokazuju različite oblike aktivacije. Oni aktiviraju mitogene response i regulišu rast i proliferaciju mnogih ćelija.

Gen

Ovaj gen kodira alfa-1B-adrenergički receptor, koji indukuje neoplastičnu transformaciju kad se transfektira u NIH 3T3 fibroblaste i druge ćelijske linije. Iz tog razloga je ovaj normalni ćelijski gen identifikovan kao protoonkogen. On se sastoji od 2 iRNK eksona i jednog velikog introna sa najmanje 20 kb.

Interakcije

Za alfa-1B adrenergički receptor je pokazano da interaguje sa AP2M1. Takođe se smatra da ima ulogu u dopaminergičkoj neurotransmisiji.

Vidi još

• Adrenergički receptor

Literatura

• Ramarao CS, Denker JM, Perez DM, et al. (1992). „Genomic organization and expression of the human alpha 1B-adrenergic receptor.”. J. Biol. Chem. 267 (30): 21936–45. PMID 1328250. 
• Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). „G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.”. Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. DOI:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393. 
• Lomasney JW, Cotecchia S, Lorenz W, et al. (1991). „Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.”. J. Biol. Chem. 266 (10): 6365–9. PMID 1706716. 
• Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). „Chromosomal organization of adrenergic receptor genes.”. Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. DOI:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750. 
• Schwinn DA, Johnston GI, Page SO, et al. (1995). „Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.”. J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325. 
• Weinberg DH, Trivedi P, Tan CP, et al. (1994). „Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.”. Biochem. Biophys. Res. Commun. 201 (3): 1296–304. DOI:10.1006/bbrc.1994.1845. PMID 8024574. 
• Forray C, Bard JA, Wetzel JM, et al. (1994). „The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.”. Mol. Pharmacol. 45 (4): 703–8. PMID 8183249. 
• Diviani D, Lattion AL, Larbi N, et al. (1996). „Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor.”. J. Biol. Chem. 271 (9): 5049–58. DOI:10.1074/jbc.271.9.5049. PMID 8617782. 
• Diviani D, Lattion AL, Cotecchia S (1997). „Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor.”. J. Biol. Chem. 272 (45): 28712–9. DOI:10.1074/jbc.272.45.28712. PMID 9353340. 
• Qian A, Wang W, Sanborn BM (1998). „Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).”. Cell. Signal. 10 (2): 101–5. DOI:10.1016/S0898-6568(97)00097-1. PMID 9481484. 
• Sasaguri T, Teruya H, Ishida A, et al. (2000). „Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells.”. Biochem. Biophys. Res. Commun. 268 (1): 25–30. DOI:10.1006/bbrc.1999.2066. PMID 10652206. 
• Minneman KP, Lee D, Zhong H, et al. (2000). „Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.”. J. Neurochem. 74 (6): 2392–400. DOI:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. 
• Shibata K, Katsuma S, Koshimizu T, et al. (2003). „alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.”. J. Biol. Chem. 278 (1): 672–8. DOI:10.1074/jbc.M201375200. PMID 12409310. 
• Diviani D, Lattion AL, Abuin L, et al. (2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.”. J. Biol. Chem. 278 (21): 19331–40. DOI:10.1074/jbc.M302110200. PMID 12644451. 
• Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, et al. (2003). „Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130.”. Mol. Pharmacol. 63 (5): 1104–16. DOI:10.1124/mol.63.5.1104. PMID 12695539. 
• Pupo AS, Minneman KP (2004). „Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.”. J. Recept. Signal Transduct. Res. 23 (2-3): 185–95. DOI:10.1081/RRS-120025200. PMID 14626446. 
• Hague C, Uberti MA, Chen Z, et al. (2004). „Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.”. J. Biol. Chem. 279 (15): 15541–9. DOI:10.1074/jbc.M314014200. PMID 14736874. 
• Kang SK, Yi KS, Kwon NS, et al. (2004). „Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits.”. J. Biol. Chem. 279 (35): 36593–600. DOI:10.1074/jbc.M402084200. PMID 15220331. 
• Gonzalez-Cabrera PJ, Shi T, Yun J, et al. (2004). „Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.”. Endocrinology 145 (11): 5157–67. DOI:10.1210/en.2004-0728. PMID 15297446. 
• Zhang T, Xu Q, Chen FR, et al. (2005). „Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.”. Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470. 

Spoljašnje veze

• „α_1B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-02-22.