Galaninski receptor 3

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Galaninski receptor 3
Identifikatori
Simboli GALR3;
Vanjski ID OMIM603692 MGI1329003 HomoloGene20798 IUPHAR: GAL3 GeneCards: GALR3 Gene
Pregled RNK izražavanja
PBB GE GALR3 33579 i at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 8484 14429
Ensembl ENSG00000128310 ENSMUSG00000047429
UniProt O60755 O88853
RefSeq (mRNA) NM_003614 XM_001001042
RefSeq (protein) NP_003605 XP_001001042
Lokacija (UCSC) Chr 22:
36.55 - 36.55 Mb
Chr 15:
78.87 - 78.87 Mb
PubMed pretraga [1] [2]

Galaninski receptor 3 (GAL3) je G protein spregnuti receptor kodiran GALR3 genom.[1]

Neuropeptid galanin modulira razne fiziološke procese kao što su kognicija/memorija, bol, hormonska sekrecija, način ishrane. Humani galaninski receptori su G protein-spregnuti receptori koji su funkcionalno spregnuti sa njihovim intracelularnim efektorima putem različitih signalnih puteva. GALR3 je nađen u mnogim tkivima i može da bude izražen kao 1.4-, 2.4-, i 5-kb transkripti.[1]

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Literatura[uredi - уреди | uredi izvor]

  • Smith KE, Walker MW, Artymyshyn R et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.". J. Biol. Chem. 273 (36): 23321–6. PMID 9722565. doi:10.1074/jbc.273.36.23321. 
  • Kolakowski LF, O'Neill GP, Howard AD et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.". J. Neurochem. 71 (6): 2239–51. PMID 9832121. doi:10.1046/j.1471-4159.1998.71062239.x. 
  • Iismaa TP, Fathi Z, Hort YJ et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes.". Ann. N. Y. Acad. Sci. 863: 56–63. PMID 9928159. doi:10.1111/j.1749-6632.1998.tb10683.x. 
  • Lapsys NM, Furler SM, Henderson NK et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3).". Mol. Cell. Probes 13 (4): 325–7. PMID 10441207. doi:10.1006/mcpr.1999.0254. 
  • Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031. 
  • Berger A, Tuechler C, Almer D et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors.". Neuroendocrinology 75 (2): 130–8. PMID 11867941. doi:10.1159/000048229. 
  • Belfer I, Hipp H, Bollettino A et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes.". Genes, Brain and Behavior 6 (5): 473–81. PMID 17083333. doi:10.1111/j.1601-183X.2006.00275.x. 
  • Runesson J, Sollenberg UE, Jurkowski W et al. (2010). "Determining receptor–ligand interaction of human galanin receptor type 3". Neurochem. Int. 57: 804–811. PMID 20817064. doi:10.1016/j.neuint.2010.08.018. 

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