Peptid YY je kratak (36-aminokiselina) protein koga oslobađaju ćelije ileuma i debelo crevo u responsu na unos hrane. Kod ljudi on umanjuje apetit. On je takođe poznat kao PYY, peptid tirozin tirozin, ili pankreasni peptid YY3-36.[1]
Peptid YY je srodan sa pankreasnom peptidnom familijom, jer je 18 od njegovih 36 aminokiselina locirano u istim pozicijama kao kod pankreasnog peptida.[2] Postoje dve glavne forme peptide YY: PYY1-36 i PYY3-36 koji imaju PP strukturni motiv. Međutim, najčešća forma cirkulišućeg PYY je PYY3-36, koja se vezuje za Y2 receptor (Y2R) Y familije receptora.[3] Peptid YY3-36 (PYY) je linearni polipeptid koji se sastoji od 36 aminokiselina.
↑DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders. str. 2754. ISBN 0-7216-2888-5.
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Tseng WW, Liu CD (2002). "Peptide YY and cancer: current findings and potential clinical applications.". Peptides23 (2): 389-95. DOI:10.1016/S0196-9781(01)00616-7. PMID11825654.
Imamura M (2002). "Effects of surgical manipulation of the intestine on peptide YY and its physiology.". Peptides23 (2): 403-7. DOI:10.1016/S0196-9781(01)00618-0. PMID11825656.
Beglinger C, Degen L (2007). "Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?". Physiol. Behav.89 (4): 460-4. DOI:10.1016/j.physbeh.2006.05.048. PMID16828127.
Eberlein GA, Eysselein VE, Schaeffer M, et al. (1989). "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).". Peptides10 (4): 797-803. DOI:10.1016/0196-9781(89)90116-2. PMID2587421.
Facer P, Bishop AE, Cole GA, et al. (1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells.". Gastroenterology97 (1): 48-57. PMID2721879.
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Lukinius AI, Ericsson JL, Lundqvist MK, Wilander EM (1986). "Ultrastructural localization of serotonin and polypeptide YY (PYY) in endocrine cells of the human rectum.". J. Histochem. Cytochem.34 (6): 719-26. PMID3517149.
Adrian TE, Ferri GL, Bacarese-Hamilton AJ, et al. (1985). "Human distribution and release of a putative new gut hormone, peptide YY.". Gastroenterology89 (5): 1070-7. PMID3840109.
Lundell I, Blomqvist AG, Berglund MM, et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem.270 (49): 29123-8. DOI:10.1074/jbc.270.49.29123. PMID7493937.
Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem.270 (45): 26762-5. DOI:10.1074/jbc.270.45.26762. PMID7592911.
Hort Y, Baker E, Sutherland GR, et al. (1995). "Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1.". Genomics26 (1): 77-83. DOI:10.1016/0888-7543(95)80085-Z. PMID7782089.
Kohri K, Nata K, Yonekura H, et al. (1993). "Cloning and structural determination of human peptide YY cDNA and gene.". Biochim. Biophys. Acta1173 (3): 345-9. PMID8318545.
Batterham RL, Heffron H, Kapoor S, Chivers J, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ (2006). "Critical role for peptide YY in protein-mediated satiation and body-weight regulation.". Cell Metabolism4 (3): 223-233. DOI:10.1016/j.cmet.2006.08.001. PMID16950139.
DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders.