Horionski gonadotropin alfa

Glikoproteinski hormoni, alfa polipeptid
	; PDB prikaz baziran na 1dz7.
Dostupne strukture
	1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9
Identifikatori
Simboli	CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
Vanjski ID	OMIM: 118850 MGI: 88390 HomoloGene: 587 GeneCards: CGA Gene
Ontologija gena
Molekularna funkcija	• hormonska aktivnost • proteinsko vezivanje
Celularna komponenta	• ekstracelularni region
Biološki proces	• formiranje tiroidnog hormona • prenos signala • međućelijska signalizacija • pozitivna regulacija ćelijske proliferacije • razvoj gonade
Pregled RNK izražavanja
	podaci
Ortolozi

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Alfa lanac glikoproteinskih hormona je protein koji je kod ljudi kodiran CGA genom.^[1]

Četiri ljudska glikoproteinska hormona: humani horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulišući hormon (FSH), i tireostimulišući hormon (TSH) su dimeri koji se sastoje od alfa i beta podjedinica, koje su nekovalentno vezane. Alfa podjedinice tih hormona su skoro identične, dok su njihovi beta lanci jedinstveni i definišu biološku specifičnost. Protein kodiran ovim genom je alfa podjedinica i pripada familiji alfa lanaca glikoproteinskih hormona.^[2]

Alfa lanac ima sledeću aminokiselinsku sekvencu:

NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

Aminokiselinska sekvena beta lanaca je:

NH2 - Ser - Lys - Glu - Pro - Leu - Arg - Pro - Arg - Cys - Arg - Pro - Ile - Asn - Ala - Thr - Leu - Ala - Val - Glu - Lys - Glu - Gly - Cys - Pro - Val - Cys - Ile - Thr - Val - Asn - Thr - Thr - Ile - Cys - Ala - Gly - Tyr - Cys - Pro - Thr - Met - Thr - Arg - Val - Leu - Gln - Gly - Val - Leu - Pro - Ala - Leu - Pro - Gln - Val - Val - Cys - Asn - Tyr - Arg - Asp - Val - Arg - Phe - Glu - Ser - Ile - Arg - Leu - Pro - Gly - Cys - Pro - Arg - Gly - Val - Asn - Pro - Val - Val - Ser - Tyr - Ala - Val - Ala - Leu - Ser - Cys - Gln - Cys - Ala - Leu - Cys - Arg - Arg - Ser - Thr - Thr - Asp - Cys - Gly - Gly - Pro - Lys - Asp - His - Pro - Leu - Thr - Cys - Asp - Asp - Pro - Arg - Phe - Gln - Asp - Ser - Ser - Ser - Ser - Lys - Ala - Pro - Pro - Pro - Ser - Leu - Pro - Ser - Pro - Ser - Arg - Leu - Pro - Gly - Pro - Ser - Asp - Thr - Pro - Ile - Leu - Pro - Gln - COOH

Reference

↑ Fiddes JC, Goodman HM (Oct 1982). „The gene encoding the common alpha subunit of the four human glycoprotein hormones”. J Mol Appl Genet 1 (1): 3–18. PMID 6286817.
↑ „Entrez Gene: CGA glycoprotein hormones, alpha polypeptide”.

Literatura

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Morgan FJ, Birken S, Canfield RE (1975). „The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.”. J. Biol. Chem. 250 (13): 5247–58. PMID 1150658.
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Sakakibara R, Yokoo Y, Yoshikoshi K, et al. (1988). „Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.”. J. Biochem. 102 (5): 993–1001. PMID 2449427.
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Lustbader JW, Birken S, Pileggi NF, et al. (1990). „Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.”. Biochemistry 28 (24): 9239–43. DOI:10.1021/bi00450a001. PMID 2611225.
Harris DC, Machin KJ, Evin GM, et al. (1989). „Preliminary X-ray diffraction analysis of human chorionic gonadotropin.”. J. Biol. Chem. 264 (12): 6705–6. PMID 2708337.
Hayashizaki Y, Miyai K, Kato K, Matsubara K (1985). „Molecular cloning of the human thyrotropin-beta subunit gene.”. FEBS Lett. 188 (2): 394–400. DOI:10.1016/0014-5793(85)80409-9. PMID 3839756.
Bellisario R, Carlsen RB, Bahl OP (1973). „Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.”. J. Biol. Chem. 248 (19): 6796–809. PMID 4745444.
Shome B, Parlow AF (1974). „Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).”. J. Clin. Endocrinol. Metab. 39 (1): 199–202. DOI:10.1210/jcem-39-1-199. PMID 4835135.

[pmid6286817-1] Fiddes JC, Goodman HM (Oct 1982). „The gene encoding the common alpha subunit of the four human glycoprotein hormones”. J Mol Appl Genet 1 (1): 3–18. PMID 6286817.

[2] „Entrez Gene: CGA glycoprotein hormones, alpha polypeptide”.

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[2]