Moždani natriuretski peptid

Izvor: Wikipedija
Prijeđi na navigaciju Prijeđi na pretragu
edit
Natriuretski peptid B
Dostupne strukture
1YK1, 3N56
Identifikatori
SimboliNPPB; BNP
Vanjski IDOMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez4879n/a
EnsemblENSG00000120937n/a
UniProtP16860n/a
RefSeq (mRNA)NM_002521.2n/a
RefSeq (protein)NP_002512.1n/a
Lokacija (UCSC)Chr 1:
11.92 - 11.92 Mb		n/a
PubMed pretraga[1]n/a

Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljud ovaj hormon uglavnom proizvode srčane komore.

BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi

Reference[uredi | uredi kod]

  1. ↑ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

Literatura[uredi | uredi kod]

  • Cosson S (2004). „Usefulness of B-type natriuretic peptide (BNP) as a screen for left ventricular abnormalities in diabetes mellitus”. Diabetes Metab. 30 (4): 381–6. DOI:10.1016/S1262-3636(07)70132-5. PMID 15525883. 
  • Cauliez B, Berthe MC, Lavoinne A (2005). „[Brain natriuretic peptide: physiological, biological and clinical aspects]”. Ann. Biol. Clin. (Paris) 63 (1): 15–25. PMID 15689309. 
  • Buchner S, Riegger G, Luchner A (2005). „[Clinical utility of the cardiac markers BNP and NT-proBNP]”. Acta Med. Austriaca 31 (4): 144–51. PMID 15732251. 
  • LaPointe MC (2005). „Molecular regulation of the brain natriuretic peptide gene”. Peptides 26 (6): 944–56. DOI:10.1016/j.peptides.2004.08.028. PMID 15911064. 
  • Hoffmann U, Borggrefe M, Brueckmann M (2006). „New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit”. Critical care (London, England) 10 (2): 134. DOI:10.1186/cc4883. PMC 1550883. PMID 16594987. 
  • Suga S, Nakao K, Hosoda K, et al. (1992). „Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide”. Endocrinology 130 (1): 229–39. DOI:10.1210/en.130.1.229. PMID 1309330. 
  • Kambayashi Y, Nakao K, Mukoyama M, et al. (1990). „Isolation and sequence determination of human brain natriuretic peptide in human atrium”. FEBS Lett. 259 (2): 341–5. DOI:10.1016/0014-5793(90)80043-I. PMID 2136732. 
  • Hino J, Tateyama H, Minamino N, et al. (1990). „Isolation and identification of human brain natriuretic peptides in cardiac atrium”. Biochem. Biophys. Res. Commun. 167 (2): 693–700. DOI:10.1016/0006-291X(90)92081-A. PMID 2138890. 
  • Sudoh T, Maekawa K, Kojima M, et al. (1989). „Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide”. Biochem. Biophys. Res. Commun. 159 (3): 1427–34. DOI:10.1016/0006-291X(89)92269-9. PMID 2522777. 
  • Seilhamer JJ, Arfsten A, Miller JA, et al. (1990). „Human and canine gene homologs of porcine brain natriuretic peptide”. Biochem. Biophys. Res. Commun. 165 (2): 650–8. DOI:10.1016/S0006-291X(89)80015-4. PMID 2597152. 
  • Arden KC, Viars CS, Weiss S, et al. (1995). „Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36”. Genomics 26 (2): 385–9. DOI:10.1016/0888-7543(95)80225-B. PMID 7601467. 
  • Weir ML, Pang SC, Flynn TG (1993). „Characterization of binding sites in rat for A, B and C-type natriuretic peptides”. Regul. Pept. 47 (3): 291–305. DOI:10.1016/0167-0115(93)90396-P. PMID 7901875. 
  • Totsune K, Takahashi K, Satoh F, et al. (1996). „Urinary immunoreactive brain natriuretic peptide in patients with renal disease”. Regul. Pept. 63 (2–3): 141–7. DOI:10.1016/0167-0115(96)00035-3. PMID 8837222. 
  • Totsune K, Takahashi K, Murakami O, et al. (1996). „Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors”. Eur. J. Endocrinol. 135 (3): 352–6. DOI:10.1530/eje.0.1350352. PMID 8890728. 
  • Matsuo K, Nishikimi T, Yutani C, et al. (1999). „Diagnostic value of plasma levels of brain natriuretic peptide in arrhythmogenic right ventricular dysplasia”. Circulation 98 (22): 2433–40. DOI:10.1161/01.CIR.98.22.2433. PMID 9832489. 
  • Wiese S, Breyer T, Dragu A, et al. (2001). „Gene expression of brain natriuretic peptide in isolated atrial and ventricular human myocardium: influence of angiotensin II and diastolic fiber length”. Circulation 102 (25): 3074–9. DOI:10.1161/01.CIR.102.25.3074. PMID 11120697. 
  • Shimizu H, Masuta K, Aono K, et al. (2002). „Molecular forms of human brain natriuretic peptide in plasma”. Clin. Chim. Acta 316 (1–2): 129–35. DOI:10.1016/S0009-8981(01)00745-8. PMID 11750283. 
  • Ogawa K, Oida A, Sugimura H, et al. (2002). „Clinical significance of blood brain natriuretic peptide level measurement in the detection of heart disease in untreated outpatients: comparison of electrocardiography, chest radiography and echocardiography”. Circ. J. 66 (2): 122–6. DOI:10.1253/circj.66.122. PMID 11999635. 
  • Asakawa H, Fukui T, Tokunaga K, Kawakami F (2002). „Plasma brain natriuretic peptide levels in normotensive Type 2 diabetic patients without cardiac disease and macroalbuminuria”. J. Diabetes Complicat. 16 (3): 209–13. DOI:10.1016/S1056-8727(01)00173-8. PMID 12015190. 
  • Bordenave L, Georges A, Bareille R, et al. (2003). „Human bone marrow endothelial cells: a new identified source of B-type natriuretic peptide”. Peptides 23 (5): 935–40. DOI:10.1016/S0196-9781(02)00004-9. PMID 12084525. 

Vidi još[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]


Izvor: https://sh.wikipedia.org/w/index.php?title=Moždani_natriuretski_peptid&oldid=5034851