Moždani natriuretski peptid
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| Natriuretski peptid B | |||||||||||
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| Dostupne strukture | |||||||||||
| 1YK1, 3N56 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | NPPB; BNP | ||||||||||
| Vanjski ID | OMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4879 | n/a | |||||||||
| Ensembl | ENSG00000120937 | n/a | |||||||||
| UniProt | P16860 | n/a | |||||||||
| RefSeq (mRNA) | NM_002521.2 | n/a | |||||||||
| RefSeq (protein) | NP_002512.1 | n/a | |||||||||
| Lokacija (UCSC) | Chr 1: 11.92 - 11.92 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljud ovaj hormon uglavnom proizvode srčane komore.
BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi
- ↑ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1
- Cosson S (2004). „Usefulness of B-type natriuretic peptide (BNP) as a screen for left ventricular abnormalities in diabetes mellitus”. Diabetes Metab. 30 (4): 381–6. DOI:10.1016/S1262-3636(07)70132-5. PMID 15525883.
- Cauliez B, Berthe MC, Lavoinne A (2005). „[Brain natriuretic peptide: physiological, biological and clinical aspects]”. Ann. Biol. Clin. (Paris) 63 (1): 15–25. PMID 15689309.
- Buchner S, Riegger G, Luchner A (2005). „[Clinical utility of the cardiac markers BNP and NT-proBNP]”. Acta Med. Austriaca 31 (4): 144–51. PMID 15732251.
- LaPointe MC (2005). „Molecular regulation of the brain natriuretic peptide gene”. Peptides 26 (6): 944–56. DOI:10.1016/j.peptides.2004.08.028. PMID 15911064.
- Hoffmann U, Borggrefe M, Brueckmann M (2006). „New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit”. Critical care (London, England) 10 (2): 134. DOI:10.1186/cc4883. PMC 1550883. PMID 16594987.
- Suga S, Nakao K, Hosoda K, et al. (1992). „Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide”. Endocrinology 130 (1): 229–39. DOI:10.1210/en.130.1.229. PMID 1309330.
- Kambayashi Y, Nakao K, Mukoyama M, et al. (1990). „Isolation and sequence determination of human brain natriuretic peptide in human atrium”. FEBS Lett. 259 (2): 341–5. DOI:10.1016/0014-5793(90)80043-I. PMID 2136732.
- Hino J, Tateyama H, Minamino N, et al. (1990). „Isolation and identification of human brain natriuretic peptides in cardiac atrium”. Biochem. Biophys. Res. Commun. 167 (2): 693–700. DOI:10.1016/0006-291X(90)92081-A. PMID 2138890.
- Sudoh T, Maekawa K, Kojima M, et al. (1989). „Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide”. Biochem. Biophys. Res. Commun. 159 (3): 1427–34. DOI:10.1016/0006-291X(89)92269-9. PMID 2522777.
- Seilhamer JJ, Arfsten A, Miller JA, et al. (1990). „Human and canine gene homologs of porcine brain natriuretic peptide”. Biochem. Biophys. Res. Commun. 165 (2): 650–8. DOI:10.1016/S0006-291X(89)80015-4. PMID 2597152.
- Arden KC, Viars CS, Weiss S, et al. (1995). „Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36”. Genomics 26 (2): 385–9. DOI:10.1016/0888-7543(95)80225-B. PMID 7601467.
- Weir ML, Pang SC, Flynn TG (1993). „Characterization of binding sites in rat for A, B and C-type natriuretic peptides”. Regul. Pept. 47 (3): 291–305. DOI:10.1016/0167-0115(93)90396-P. PMID 7901875.
- Totsune K, Takahashi K, Satoh F, et al. (1996). „Urinary immunoreactive brain natriuretic peptide in patients with renal disease”. Regul. Pept. 63 (2–3): 141–7. DOI:10.1016/0167-0115(96)00035-3. PMID 8837222.
- Totsune K, Takahashi K, Murakami O, et al. (1996). „Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors”. Eur. J. Endocrinol. 135 (3): 352–6. DOI:10.1530/eje.0.1350352. PMID 8890728.
- Matsuo K, Nishikimi T, Yutani C, et al. (1999). „Diagnostic value of plasma levels of brain natriuretic peptide in arrhythmogenic right ventricular dysplasia”. Circulation 98 (22): 2433–40. DOI:10.1161/01.CIR.98.22.2433. PMID 9832489.
- Wiese S, Breyer T, Dragu A, et al. (2001). „Gene expression of brain natriuretic peptide in isolated atrial and ventricular human myocardium: influence of angiotensin II and diastolic fiber length”. Circulation 102 (25): 3074–9. DOI:10.1161/01.CIR.102.25.3074. PMID 11120697.
- Shimizu H, Masuta K, Aono K, et al. (2002). „Molecular forms of human brain natriuretic peptide in plasma”. Clin. Chim. Acta 316 (1–2): 129–35. DOI:10.1016/S0009-8981(01)00745-8. PMID 11750283.
- Ogawa K, Oida A, Sugimura H, et al. (2002). „Clinical significance of blood brain natriuretic peptide level measurement in the detection of heart disease in untreated outpatients: comparison of electrocardiography, chest radiography and echocardiography”. Circ. J. 66 (2): 122–6. DOI:10.1253/circj.66.122. PMID 11999635.
- Asakawa H, Fukui T, Tokunaga K, Kawakami F (2002). „Plasma brain natriuretic peptide levels in normotensive Type 2 diabetic patients without cardiac disease and macroalbuminuria”. J. Diabetes Complicat. 16 (3): 209–13. DOI:10.1016/S1056-8727(01)00173-8. PMID 12015190.
- Bordenave L, Georges A, Bareille R, et al. (2003). „Human bone marrow endothelial cells: a new identified source of B-type natriuretic peptide”. Peptides 23 (5): 935–40. DOI:10.1016/S0196-9781(02)00004-9. PMID 12084525.