Osteokalcin (koštani protein koji sadrži gama-karboksiglutaminsku kiselinu, BGLAP) je nonkolagenozni protein nađen u kostima i dentinu. Kod ljudi, osteocalcin je kodiran BGLAPgenom.[1][2]
Osteokalcin izlučuju isključivo osteoblasti. Smatra se da on ima ulogu u telesnoj metaboličkoj regulaciji i formiranju kostiju.[3] On je takođe impliciran u koštanu mineralizaciju i homeostazu jona kalcijuma. On deluje kao hormon u telu, koji stimuliše beta ćelije u pankreasu da otpuste više insulina, i istovremeno usmerava ćelije masnoće da otpuštaju hormon adiponektin, koji povećava senzitivnost na insulin.[3]
↑Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology124 (5): 2648–50. PMID2785029. doi:10.1210/endo-124-5-2648.Cite uses deprecated parameter |month= (help)
↑Cancela L, Hsieh CL, Francke U, Price PA (September 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". J. Biol. Chem.265 (25): 15040–8. PMID2394711.Cite uses deprecated parameter |month= (help)
Kamdem LK, Hamilton L, Cheng C et al. (2008). "Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.". Pharmacogenet. Genomics18 (6): 507–14. PMID18496130. doi:10.1097/FPC.0b013e3282fc5801.CS1 održavanje: Eksplicitna upotreba et al. (link)
Lin GT, Tseng HF, Chang CK et al. (2008). "SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.". Chin J Physiol51 (1): 32–41. PMID18551993.CS1 održavanje: Eksplicitna upotreba et al. (link)
Lumachi F, Camozzi V, Tombolan V, Luisetto G (2009). "Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.". Ann. N. Y. Acad. Sci. 1173 Suppl 1: E64–7. PMID19751417. doi:10.1111/j.1749-6632.2009.04955.x.
Kanazawa I, Yamaguchi T, Yamamoto M et al. (2009). "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.". Calcif. Tissue Int.85 (3): 228–34. PMID19641839. doi:10.1007/s00223-009-9272-4.CS1 održavanje: Eksplicitna upotreba et al. (link)
Makita N, Suzuki M, Asami S et al. (2008). "Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells.". Gene413 (1-2): 8–17. PMID18321663. doi:10.1016/j.gene.2007.12.025.CS1 održavanje: Eksplicitna upotreba et al. (link)
Desbois C, Karsenty G (1995). "Osteocalcin cluster: implications for functional studies.". J. Cell. Biochem.57 (3): 379–83. PMID7768973. doi:10.1002/jcb.240570302.
Salem AM, Zohny SF, Abd El-Wahab MM, Hamdy R (2007). "Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer.". Clin. Biochem.40 (16-17): 1201–8. PMID17889845. doi:10.1016/j.clinbiochem.2007.07.006.
Im JA, Yu BP, Jeon JY, Kim SH (2008). "Relationship between osteocalcin and glucose metabolism in postmenopausal women.". Clin. Chim. Acta396 (1-2): 66–9. PMID18657532. doi:10.1016/j.cca.2008.07.001.
Ba Y, Huang H, Yang Y et al. (2009). "The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China.". Ecotoxicol. Environ. Saf.72 (8): 2158–61. PMID19767102. doi:10.1016/j.ecoenv.2009.08.014.CS1 održavanje: Eksplicitna upotreba et al. (link)
Hwang YC, Jeong IK, Ahn KJ, Chung HY (2009). "The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects.". Diabetes Metab. Res. Rev.25 (8): 768–72. PMID19877133. doi:10.1002/dmrr.1045.
Yu S, Jiang Y, Galson DL et al. (2008). "General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2.". J. Biol. Chem.283 (9): 5542–53. PMID18171674. doi:10.1074/jbc.M705653200.CS1 održavanje: Eksplicitna upotreba et al. (link)
Kayed H, Bekasi S, Keleg S et al. (2007). "BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.". Mol. Cancer6: 83. PMID18163903. doi:10.1186/1476-4598-6-83.CS1 održavanje: Eksplicitna upotreba et al. (link)
French D, Hamilton LH, Mattano LA et al. (2008). "A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.". Blood111 (9): 4496–9. PMID18285546. doi:10.1182/blood-2007-11-123885.CS1 održavanje: Eksplicitna upotreba et al. (link)
Pittas AG, Harris SS, Eliades M et al. (2009). "Association between serum osteocalcin and markers of metabolic phenotype.". J. Clin. Endocrinol. Metab.94 (3): 827–32. PMID19088165. doi:10.1210/jc.2008-1422.CS1 održavanje: Eksplicitna upotreba et al. (link)
Kindblom JM, Ohlsson C, Ljunggren O et al. (2009). "Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.". J. Bone Miner. Res.24 (5): 785–91. PMID19063687. doi:10.1359/jbmr.081234.CS1 održavanje: Eksplicitna upotreba et al. (link)
Wahlgren CM, Zheng W, Shaalan W et al. (2009). "Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology.". Cerebrovasc. Dis.27 (2): 193–200. PMID19136823. doi:10.1159/000189204.CS1 održavanje: Eksplicitna upotreba et al. (link)
Lumachi F, Ermani M, Camozzi V et al. (2009). "Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis.". Ann. N. Y. Acad. Sci. 1173 Suppl 1: E60–3. PMID19751416. doi:10.1111/j.1749-6632.2009.04953.x.CS1 održavanje: Eksplicitna upotreba et al. (link)
Born AK, Rottmar M, Lischer S et al. (2009). "Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring.". Eur Cell Mater18: 49–60, 61–2; discussion 60. PMID19856264.CS1 održavanje: Eksplicitna upotreba et al. (link)
Fujisawa R (2002). "[Recent advances in research on bone matrix proteins]". Nippon Rinsho. 60 Suppl 3: 72–8. PMID11979972.