Osteokalcin

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Koštani gama-karboksiglutamatni (gla) protein

PDB prikaz baziran na 1q8h.
Dostupne strukture
1q3m, 1q8h
Identifikatori
Simboli BGLAP; BGP; OC
Vanjski ID OMIM: 112260 MGI: 88156 HomoloGene: 104130 GeneCards: BGLAP Gene
Ortolozi
Vrsta Čovek Miš
Entrez 632 12095
Ensembl ENSG00000242252 ENSMUSG00000074489
UniProt P02818 P54615
RefSeq (mRNA) NM_199173.4 NM_031368.4
RefSeq (protein) NP_954642.1 NP_112736.3
Lokacija (UCSC) Chr 1:
156.21 - 156.21 Mb		 Chr 3:
88.17 - 88.18 Mb
PubMed pretraga [1] [2]

Osteokalcin (koštani protein koji sadrži gama-karboksiglutaminsku kiselinu, BGLAP) je nonkolagenozni protein nađen u kostima i dentinu. Kod ljudi, osteocalcin je kodiran BGLAP genom.[1][2]

Funkcija[uredi - уреди | uredi izvor]

Osteokalcin izlučuju isključivo osteoblasti. Smatra se da on ima ulogu u telesnoj metaboličkoj regulaciji i formiranju kostiju.[3] On je takođe impliciran u koštanu mineralizaciju i homeostazu jona kalcijuma. On deluje kao hormon u telu, koji stimuliše beta ćelije u pankreasu da otpuste više insulina, i istovremeno usmerava ćelije masnoće da otpuštaju hormon adiponektin, koji povećava senzitivnost na insulin.[3]

Reference[uredi - уреди | uredi izvor]

  1. ↑ Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology 124 (5): 2648–50. PMID 2785029. doi:10.1210/endo-124-5-2648. 
  2. ↑ Cancela L, Hsieh CL, Francke U, Price PA (September 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". J. Biol. Chem. 265 (25): 15040–8. PMID 2394711. 
  3. ↑ 3,0 3,1 Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (August 2007). "Endocrine regulation of energy metabolism by the skeleton". Cell 130 (3): 456–69. PMC 2013746. PMID 17693256. doi:10.1016/j.cell.2007.05.047. 

Literatura[uredi - уреди | uredi izvor]

  • Kamdem LK, Hamilton L, Cheng C et al. (2008). "Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.". Pharmacogenet. Genomics 18 (6): 507–14. PMID 18496130. doi:10.1097/FPC.0b013e3282fc5801. 
  • Lin GT, Tseng HF, Chang CK et al. (2008). "SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.". Chin J Physiol 51 (1): 32–41. PMID 18551993. 
  • Lumachi F, Camozzi V, Tombolan V, Luisetto G (2009). "Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.". Ann. N. Y. Acad. Sci. 1173 Suppl 1: E64–7. PMID 19751417. doi:10.1111/j.1749-6632.2009.04955.x. 
  • Kanazawa I, Yamaguchi T, Yamamoto M et al. (2009). "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.". Calcif. Tissue Int. 85 (3): 228–34. PMID 19641839. doi:10.1007/s00223-009-9272-4. 
  • Makita N, Suzuki M, Asami S et al. (2008). "Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells.". Gene 413 (1-2): 8–17. PMID 18321663. doi:10.1016/j.gene.2007.12.025. 
  • Desbois C, Karsenty G (1995). "Osteocalcin cluster: implications for functional studies.". J. Cell. Biochem. 57 (3): 379–83. PMID 7768973. doi:10.1002/jcb.240570302. 
  • Salem AM, Zohny SF, Abd El-Wahab MM, Hamdy R (2007). "Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer.". Clin. Biochem. 40 (16-17): 1201–8. PMID 17889845. doi:10.1016/j.clinbiochem.2007.07.006. 
  • Im JA, Yu BP, Jeon JY, Kim SH (2008). "Relationship between osteocalcin and glucose metabolism in postmenopausal women.". Clin. Chim. Acta 396 (1-2): 66–9. PMID 18657532. doi:10.1016/j.cca.2008.07.001. 
  • Ba Y, Huang H, Yang Y et al. (2009). "The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China.". Ecotoxicol. Environ. Saf. 72 (8): 2158–61. PMID 19767102. doi:10.1016/j.ecoenv.2009.08.014. 
  • Hwang YC, Jeong IK, Ahn KJ, Chung HY (2009). "The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects.". Diabetes Metab. Res. Rev. 25 (8): 768–72. PMID 19877133. doi:10.1002/dmrr.1045. 
  • Yerges LM, Klei L, Cauley JA et al. (2009). "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.". J. Bone Miner. Res. 24 (12): 2039–49. PMC 2791518. PMID 19453261. doi:10.1359/jbmr.090524. 
  • Yu S, Jiang Y, Galson DL et al. (2008). "General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2.". J. Biol. Chem. 283 (9): 5542–53. PMID 18171674. doi:10.1074/jbc.M705653200. 
  • Kayed H, Bekasi S, Keleg S et al. (2007). "BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.". Mol. Cancer 6: 83. PMID 18163903. doi:10.1186/1476-4598-6-83. 
  • French D, Hamilton LH, Mattano LA et al. (2008). "A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.". Blood 111 (9): 4496–9. PMID 18285546. doi:10.1182/blood-2007-11-123885. 
  • Pittas AG, Harris SS, Eliades M et al. (2009). "Association between serum osteocalcin and markers of metabolic phenotype.". J. Clin. Endocrinol. Metab. 94 (3): 827–32. PMID 19088165. doi:10.1210/jc.2008-1422. 
  • Kindblom JM, Ohlsson C, Ljunggren O et al. (2009). "Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.". J. Bone Miner. Res. 24 (5): 785–91. PMID 19063687. doi:10.1359/jbmr.081234. 
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  • Lumachi F, Ermani M, Camozzi V et al. (2009). "Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis.". Ann. N. Y. Acad. Sci. 1173 Suppl 1: E60–3. PMID 19751416. doi:10.1111/j.1749-6632.2009.04953.x. 
  • Born AK, Rottmar M, Lischer S et al. (2009). "Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring.". Eur Cell Mater 18: 49–60, 61–2; discussion 60. PMID 19856264. 
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