Osteokalcin (koštani protein koji sadrži gama-karboksiglutaminsku kiselinu, BGLAP) je nonkolagenozni protein nađen u kostima i dentinu. Kod ljudi, osteocalcin je kodiran BGLAPgenom.[1][2]
Osteokalcin izlučuju isključivo osteoblasti. Smatra se da on ima ulogu u telesnoj metaboličkoj regulaciji i formiranju kostiju.[3] On je takođe impliciran u koštanu mineralizaciju i homeostazu jona kalcijuma. On deluje kao hormon u telu, koji stimuliše beta ćelije u pankreasu da otpuste više insulina, i istovremeno usmerava ćelije masnoće da otpuštaju hormon adiponektin, koji povećava senzitivnost na insulin.[3]
↑Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology124 (5): 2648–50. DOI:10.1210/endo-124-5-2648. PMID2785029.
↑Cancela L, Hsieh CL, Francke U, Price PA (September 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". J. Biol. Chem.265 (25): 15040–8. PMID2394711.
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Pittas AG, Harris SS, Eliades M, et al. (2009). "Association between serum osteocalcin and markers of metabolic phenotype.". J. Clin. Endocrinol. Metab.94 (3): 827–32. DOI:10.1210/jc.2008-1422. PMID19088165.
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