Neurotenzinski receptor 1

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Neurotenzinski receptor 1
Identifikatori
SimboliNTSR1; NTR
Vanjski IDOMIM162651 MGI97386 HomoloGene68261 IUPHAR: NTS1 GeneCards: NTSR1 Gene
Pregled RNK izražavanja
PBB GE NTSR1 207360 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez492318216
EnsemblENSG00000101188ENSMUSG00000027568
UniProtP30989Q9QZQ2
RefSeq (mRNA)NM_002531XM_989244
RefSeq (protein)NP_002522XP_994338
Lokacija (UCSC)Chr 20:
60.81 - 60.86 Mb
Chr 2:
180.43 - 180.47 Mb
PubMed pretraga[1][2]

Neurotenzinski receptor tip 1 je protein koji je kod ljudi kodiran NTSR1 genom.[1][2]

Neurotenzinski receptor 1 pripada velikoj familiji G-protein spregnutih receptora. NTSR1 posreduje višestruke funkcije neurotenzina, kao što je hipotenzija, hiperglicemija, hipotermija, antinocicepcija, i regulacija intestinalne motilnosti i sekrecije.[2]

Vidi još[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  1. Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D, Rostene W (Oct 1994). "Chromosomal localization of mouse and human neurotensin receptor genes". Mamm Genome 5 (5): 303–6. PMID 8075503. doi:10.1007/BF00389545.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923. 

Dodatna literatura[uredi - уреди | uredi izvor]

  • Vincent JP (1996). "Neurotensin receptors: binding properties, transduction pathways, and structure.". Cell. Mol. Neurobiol. 15 (5): 501–12. PMID 8719037. doi:10.1007/BF02071313. 
  • Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors.". Trends Pharmacol. Sci. 20 (7): 302–9. PMID 10390649. doi:10.1016/S0165-6147(99)01357-7. 
  • Vita N, Laurent P, Lefort S et al. (1993). "Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor.". FEBS Lett. 317 (1-2): 139–42. PMID 8381365. doi:10.1016/0014-5793(93)81509-X. 
  • Le F, Groshan K, Zeng XP, Richelson E (1997). "Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene.". J. Biol. Chem. 272 (2): 1315–22. PMID 8995438. doi:10.1074/jbc.272.2.1315. 
  • Boudin H, Pélaprat D, Rostène W et al. (1998). "Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra.". J. Neurosci. 18 (20): 8473–84. PMID 9763490. 
  • Ye X, Mehlen P, Rabizadeh S et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. PMID 10514511. doi:10.1074/jbc.274.42.30202. 
  • Wang L, Friess H, Zhu Z et al. (2000). "Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease.". Clin. Cancer Res. 6 (2): 566–71. PMID 10690540. 
  • Cusack B, Jansen K, McCormick DJ et al. (2000). "A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.". Biochem. Pharmacol. 60 (6): 793–801. PMID 10930533. doi:10.1016/S0006-2952(00)00409-3. 
  • Oakley RH, Laporte SA, Holt JA et al. (2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.". J. Biol. Chem. 276 (22): 19452–60. PMID 11279203. doi:10.1074/jbc.M101450200. 
  • Leplatois P, Josse A, Guillemot M et al. (2001). "Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor.". Eur. J. Biochem. 268 (18): 4860–7. PMID 11559354. doi:10.1046/j.0014-2956.2001.02407.x. 
  • Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a. 
  • Lundquist JT, Büllesbach EE, Golden PL, Dix TA (2002). "Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs.". J. Pept. Res. 59 (2): 55–61. PMID 11906607. 
  • Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (2): 482–8. PMID 12150975. doi:10.1016/S0006-291X(02)00703-9. 
  • Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.". Gastroenterology 123 (4): 1135–43. PMID 12360476. doi:10.1053/gast.2002.36000. 
  • Toy-Miou-Leong M, Cortes CL, Beaudet A et al. (2004). "Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation.". J. Biol. Chem. 279 (13): 12636–46. PMID 14699144. doi:10.1074/jbc.M303384200. 
  • Magazin M, Poszepczynska-Guigné E, Bagot M et al. (2004). "Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor.". J. Invest. Dermatol. 122 (1): 111–8. PMID 14962098. doi:10.1046/j.0022-202X.2003.22131.x. 
  • Brun P, Mastrotto C, Beggiao E et al. (2005). "Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G621–9. PMID 15764810. doi:10.1152/ajpgi.00140.2004. 

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