Sigma-2 receptor

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Sigma-2 receptor („σ2R“) je sigma receptor koji preferentno vezuje siramesin[1] i PB28.[2]

Aktivacija ovog receptora može da uzrokuje apoptozu.[3] 3E farmakofor model sigma2 receptora baziran na seriji supstituisanih benzo[d]oksazol-2(3H)-on derivata je objavljen.[4]

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Literatura[uredi - уреди | uredi izvor]

  1. Skuza G, Rogóz Z (2006). "The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats". J. Physiol. Pharmacol. 57 (2): 217–29. PMID 16845227. 
  2. Cassano G, Gasparre G, Contino M et al. (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium 40 (1): 23–8. PMID 16687172. doi:10.1016/j.ceca.2006.03.004. 
  3. Bowen WD (March 2000). "Sigma receptors: recent advances and new clinical potentials". Pharm Acta Helv 74 (2–3): 211–8. PMID 10812960. doi:10.1016/S0031-6865(99)00034-5. 
  4. Laurini E, Zampieri D, Mamolo MG, Vio L, Zanette C, Florio C, Posocco P, Fermeglia M, Pricl S (May 2010). "A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives". Bioorg. Med. Chem. Lett. 20 (9): 2954–7. PMID 20347592. doi:10.1016/j.bmcl.2010.03.009. 

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