Bradikininski receptor B1

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Bradikininski receptor B1
Identifikatori
SimboliBDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1
Vanjski IDOMIM600337 MGI88144 HomoloGene570 IUPHAR: B1 GeneCards: BDKRB1 Gene
Pregled RNK izražavanja
PBB GE BDKRB1 207510 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez62312061
EnsemblENSG00000100739ENSMUSG00000041347
UniProtP46663Q0VBD7
RefSeq (mRNA)NM_000710NM_007539
RefSeq (protein)NP_000701NP_031565
Lokacija (UCSC)Chr 14:
95.8 - 95.8 Mb
Chr 12:
106.01 - 106.01 Mb
PubMed pretraga[1][2]

Bradikininski receptor B1 (B1) je G-protein spregnuti receptor kodiran BDKRB1 genom kod ljudi. Njegov principalni ligand je bradikinin, peptid sa 9 aminokiselina koji se formira u patofiziološkim uslovima kao što je inflamacija, trauma, opekotine, šok, i alergija. B1 receptor je jedan od dva G protein-spregnuta receptora za koje je utvrđeno da vezuju bradikinin i posreduju response na te patofiziološke uslove.

B1 protein se sintetiše de novo nakon povrede tkiva. Njegovo vezivanje za receptor dovodi do povećanja citosolne koncentracije jona kalcijuma, što ultimatno dovodi do hroničnog i akutnog inflamatornog responsa.[1]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

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  • Newton R, Eddleston J, Haddad el-B et al. (2002). "Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.". Eur. J. Pharmacol. 441 (3): 193–202. PMID 12063092. doi:10.1016/S0014-2999(01)01624-7. 
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  • Lamb ME, Zhang C, Shea T et al. (2003). "Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.". Biochemistry 41 (48): 14340–7. PMID 12450400. doi:10.1021/bi020231d. 
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