Alfa-2B adrenergički receptor

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Adrenergički alfa-2B receptor
Identifikatori
SimboliADRA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR
Vanjski IDOMIM104260 MGI87935 HomoloGene553 IUPHAR: α2B-adrenoceptor GeneCards: ADRA2B Gene
Ortolozi
VrstaČovekMiš
Entrez15111552
Ensembln/aENSMUSG00000058620
UniProtP18089P30545
RefSeq (mRNA)NM_000682NM_009633
RefSeq (protein)NP_000673NP_033763
Lokacija (UCSC)n/aChr 2:
127.05 - 127.06 Mb
PubMed pretraga[1][2]

Alfa-2B adrenergički receptor (α2B adrenoceptor) je G-protein spregnuti receptor. On je tip adrenergičke receptorske familije. Humani gen koji kodira ovaj receptor ima simbol ADRA2B.[1] ADRA2B ortolozi[2] su identifikovani kod nekoliko sisara.

Receptor[uredi - уреди | uredi izvor]

Postoje tri visoko homologna tipa alfa-2-adrenergičkog receptora: alfa2A, alfa2B, i alfa2C. Ti receptori učestvuju u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema.

Gen[uredi - уреди | uredi izvor]

Ovaj gen kodira alfa2B tip receptora. On se vezuje za eIF-2B, faktor razmene guanin nukleotida koji učestvuje u regulaciji translacije. Za polimorfnu varijantu alfa2B tip, kojoj nedostaju 3 glutaminske kiseline iz elementa ponavljanja glutaminskih kiselina, je ustanoljeno da ima umanjenu GPCR kinazama-posredovanu fosforilaciju i desenzitizaciju. Ova polimorfna forma je isto tako povezana sa umanjenom bazalnim metabolizmom kod gojaznih osoba i moguće je da doprinosi patogenezi gojaznosti. Ovaj gen ne sadrži introne.[1]

Selektivni ligandi[uredi - уреди | uredi izvor]

Antagonisti[uredi - уреди | uredi izvor]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Lomasney JW, Lorenz W, Allen LF et al. (1990). "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. PMC 54268. PMID 2164221. doi:10.1073/pnas.87.13.5094. 
  • McClue SJ, Milligan G (1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.". FEBS Lett. 269 (2): 430–4. PMID 2169434. doi:10.1016/0014-5793(90)81209-7. 
  • Weinshank RL, Zgombick JM, Macchi M et al. (1990). "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.". Mol. Pharmacol. 38 (5): 681–8. PMID 2172775. 
  • Chang AC, Ho TF, Chang NC (1990). "In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.". Biochem. Biophys. Res. Commun. 172 (2): 817–23. PMID 2173582. doi:10.1016/0006-291X(90)90748-C. 
  • Regan JW, Kobilka TS, Yang-Feng TL et al. (1988). "Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. PMC 281957. PMID 2842764. doi:10.1073/pnas.85.17.6301. 
  • Petrash AC, Bylund DB (1986). "Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.". Life Sci. 38 (23): 2129–37. PMID 3012234. doi:10.1016/0024-3205(86)90212-2. 
  • Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.". J. Biol. Chem. 272 (31): 19099–102. PMID 9235896. doi:10.1074/jbc.272.31.19099. 
  • Okusa MD, Huang L, Momose-Hotokezaka A et al. (1998). "Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.". Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676. 
  • Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.". J. Biol. Chem. 274 (19): 13462–9. PMID 10224112. doi:10.1074/jbc.274.19.13462. 
  • Heinonen P, Koulu M, Pesonen U et al. (1999). "Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.". J. Clin. Endocrinol. Metab. 84 (7): 2429–33. PMID 10404816. doi:10.1210/jc.84.7.2429. 
  • Hein L, Altman JD, Kobilka BK (2000). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.". Nature 402 (6758): 181–4. PMID 10647009. doi:10.1038/46040. 
  • Small KM, Brown KM, Forbes SL, Liggett SB (2001). "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.". J. Biol. Chem. 276 (7): 4917–22. PMID 11056163. doi:10.1074/jbc.M008118200. 
  • Snapir A, Mikkelsson J, Perola M et al. (2003). "Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.". J. Am. Coll. Cardiol. 41 (2): 190–4. PMID 12535806. doi:10.1016/S0735-1097(02)02702-X. 
  • Sykiotis GP, Polyzogopoulou E, Georgopoulos NA et al. (2004). "The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.". Clin. Auton. Res. 13 (3): 203–7. PMID 12822042. doi:10.1007/s10286-003-0087-5. 
  • Chotani MA, Mitra S, Su BY et al. (2004). "Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.". Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. PMID 12946937. doi:10.1152/ajpheart.00268.2003. 
  • Von Wowern F, Bengtsson K, Lindblad U et al. (2004). "Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.". Hypertension 43 (3): 592–7. PMID 14744925. doi:10.1161/01.HYP.0000116224.51189.80. 
  • Cayla C, Heinonen P, Viikari L et al. (2004). "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.". Biochem. Pharmacol. 67 (3): 469–78. PMID 15037199. doi:10.1016/j.bcp.2003.09.029. 
  • Phares DA, Halverstadt AA, Shuldiner AR et al. (2004). "Association between body fat response to exercise training and multilocus ADR genotypes.". Obes. Res. 12 (5): 807–15. PMID 15166301. doi:10.1038/oby.2004.97. 
  • Siitonen N, Lindström J, Eriksson J et al. (2005). "Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.". Diabetologia 47 (8): 1416–24. PMID 15309292. doi:10.1007/s00125-004-1462-z. 
  • Belfer I, Buzas B, Hipp H et al. (2005). "Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.". J. Hum. Genet. 50 (1): 12–20. PMID 15592690. doi:10.1007/s10038-004-0211-y. 

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