FSH-receptor

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Struktura interakcije FSH i FSH-receptora

PDB prikaz baziran na 1xwd.
Dostupne strukture
1xwd
Identifikatori
SimboliFSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1
Vanjski IDOMIM136435 MGI95583 HomoloGene117 IUPHAR: FSH GeneCards: FSHR Gene
Pregled RNK izražavanja
PBB GE FSHR 211201 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez249214309
EnsemblENSG00000170820ENSMUSG00000032937
UniProtP23945P35378
RefSeq (mRNA)NM_000145NM_013523
RefSeq (protein)NP_000136NP_038551
Lokacija (UCSC)Chr 2:
49.04 - 49.24 Mb
Chr 17:
88.89 - 89.11 Mb
PubMed pretraga[1][2]

Folikulostimulišući hormonski receptor ili FSH-receptor (FSHR) je transmembranski receptor koji interaguje sa Folikulostimulišućim hormonom (FSH). On je G protein-spregnuti receptor (GPCR). Njegova aktivacija je neophodna za FSH hormonsko funkcionisanje. FSHR receptori su nađeni u jajnicima, testisima, i uterusu.

FSHR gen[uredi - уреди | uredi izvor]

FSHR gen se nalazi na hromozomu 2 p21 kod čoveka. FSHR genska sekvenca se sastoji od oko 2,080 nukleotida.[1]

Struktura receptora[uredi - уреди | uredi izvor]

Struktura G protein-spregnutog receptora kao što je FSHR sa sedam transmembranskih α-heliksa

FSHR se sastoji od 695 aminokiselina, i ima molekulsku masu od oko 76 kDa.[1] Poput drugih GPCR receptora, FSH-receptor poseduje sedam domena (transmembranskih heliksa), svaki od kojih premoštava membranu.

  • Transmembranski domen sadrži dva visoko očuvana cisteinska ostatka koji formiraju disulfidnu vezs čime se stabilizuje struktura receptora. Visoko konzervirani Asp-Arg-Tyr triplet je prisutan i verovatno učestvuje u prenosu signala.

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 Simoni M, Gromoll J, Nieschlag E (December 1997). "The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology". Endocr. Rev. 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739. 

Literatura[uredi - уреди | uredi izvor]

  • de la Chapelle A (1993). "Disease gene mapping in isolated human populations: the example of Finland.". J. Med. Genet. 30 (10): 857–65. PMC 1016570. PMID 8230163. doi:10.1136/jmg.30.10.857. 
  • Amsterdam A, Hanoch T, Dantes A et al. (2003). "Mechanisms of gonadotropin desensitization.". Mol. Cell. Endocrinol. 187 (1-2): 69–74. PMID 11988313. doi:10.1016/S0303-7207(01)00701-8. 
  • Simoni M, Nieschlag E, Gromoll J (2003). "Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction.". Hum. Reprod. Update 8 (5): 413–21. PMID 12398222. doi:10.1093/humupd/8.5.413. 
  • Delbaere A, Smits G, Olatunbosun O et al. (2004). "New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?". Hum. Reprod. 19 (3): 486–9. PMC 2891954. PMID 14998941. doi:10.1093/humrep/deh124. 
  • Bose CK (2005). "Role of nerve growth factor and FSH receptor in epithelial ovarian cancer.". Reprod. Biomed. Online 11 (2): 194–7. PMID 16168216. doi:10.1016/S1472-6483(10)60958-3. 
  • Wunsch A, Sonntag B, Simoni M (2007). "Polymorphism of the FSH receptor and ovarian response to FSH.". Ann. Endocrinol. (Paris) 68 (2-3): 160–6. PMID 17544358. doi:10.1016/j.ando.2007.04.006. 
  • Kelton CA, Cheng SV, Nugent NP et al. (1993). "The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.". Mol. Cell. Endocrinol. 89 (1-2): 141–51. PMID 1301382. doi:10.1016/0303-7207(92)90220-Z. 
  • Tilly JL, Aihara T, Nishimori K et al. (1992). "Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.". Endocrinology 131 (2): 799–806. PMID 1322283. doi:10.1210/en.131.2.799. 
  • Gromoll J, Gudermann T, Nieschlag E (1992). "Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.". Biochem. Biophys. Res. Commun. 188 (3): 1077–83. PMID 1359889. doi:10.1016/0006-291X(92)91341-M. 
  • Minegishi T, Nakamura K, Takakura Y et al. (1991). "Cloning and sequencing of human FSH receptor cDNA.". Biochem. Biophys. Res. Commun. 175 (3): 1125–30. PMID 1709010. doi:10.1016/0006-291X(91)91682-3. 
  • Gromoll J, Ried T, Holtgreve-Grez H et al. (1994). "Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10.". J. Mol. Endocrinol. 12 (3): 265–71. PMID 7916967. doi:10.1677/jme.0.0120265. 
  • Gromoll J, Dankbar B, Gudermann T (1994). "Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.". Mol. Cell. Endocrinol. 102 (1-2): 93–102. PMID 7926278. doi:10.1016/0303-7207(94)90102-3. 
  • Rousseau-Merck MF, Atger M, Loosfelt H et al. (1993). "The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene.". Genomics 15 (1): 222–4. PMID 8432542. doi:10.1006/geno.1993.1041. 
  • Jiang X, Dreano M, Buckler DR et al. (1996). "Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.". Structure 3 (12): 1341–53. PMID 8747461. doi:10.1016/S0969-2126(01)00272-6. 
  • Aittomäki K, Herva R, Stenman UH et al. (1996). "Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene.". J. Clin. Endocrinol. Metab. 81 (10): 3722–6. PMID 8855829. doi:10.1210/jc.81.10.3722. 
  • Tapanainen JS, Aittomäki K, Min J et al. (1997). "Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility.". Nat. Genet. 15 (2): 205–6. PMID 9020851. doi:10.1038/ng0297-205. 
  • Kotlar TJ, Young RH, Albanese C et al. (1997). "A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.". J. Clin. Endocrinol. Metab. 82 (4): 1020–6. PMID 9100567. doi:10.1210/jc.82.4.1020. 

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