S1PR3

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Sfingozin-1-fosfatni receptor 3
Identifikatori
SimboliS1PR3; EDG-3; EDG3; LPB3; S1P3
Vanjski IDOMIM601965 MGI1339365 HomoloGene3829 IUPHAR: S1P3
Ortolozi
VrstaČovekMiš
Entrezn/a13610
EnsemblENSG00000213694ENSMUSG00000067586
UniProtQ99500Q9Z0U9
RefSeq (mRNA)NM_005226.3NM_010101.4
RefSeq (protein)NP_005217.2NP_034231.1
Lokacija (UCSC)Chr 9:
91.61 - 91.62 Mb
Chr 13:
51.5 - 51.52 Mb
PubMed pretragan/a[1]

Sfingozin-1-fosfatni receptor 3 je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P). stoga je ovaj receptor takođe poznat kao S1P3.[1]

Funkcija[uredi - уреди | uredi izvor]

Ovaj protein je član EDG familije receptora. On doprinosi regulaciji angiogeneze i funkcija vaskularnih endotelnih ćelija.[1]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Hla T, Lee MJ, Ancellin N et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 16–24. PMID 10818438. doi:10.1111/j.1749-6632.2000.tb06534.x. 
  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x. 
  • Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing.". Ann. N. Y. Acad. Sci. 905: 142–58. PMID 10818450. doi:10.1111/j.1749-6632.2000.tb06546.x. 
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348. 
  • Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355. 
  • Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608–14. PMID 8878560. doi:10.1006/bbrc.1996.1553. 
  • An S, Bleu T, Huang W et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. PMID 9409733. doi:10.1016/S0014-5793(97)01301-X. 
  • Van Brocklyn JR, Tu Z, Edsall LC et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626–32. PMID 9988698. doi:10.1074/jbc.274.8.4626. 
  • Zhang Q, Peyruchaud O, French KJ et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.". Blood 93 (9): 2984–90. PMID 10216094. 
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399. doi:10.1074/jbc.274.27.18997. 
  • Windh RT, Lee MJ, Hla T et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065. doi:10.1074/jbc.274.39.27351. 
  • Goetzl EJ, Dolezalova H, Kong Y et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.". Cancer Res. 59 (20): 5370–5. PMID 10537322. 
  • Lee MJ, Thangada S, Claffey KP et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. PMID 10555146. doi:10.1016/S0092-8674(00)81661-X. 
  • An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288–96. PMID 10617617. doi:10.1074/jbc.275.1.288. 
  • Orlati S, Porcelli AM, Hrelia S et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.". Arch. Biochem. Biophys. 375 (1): 69–77. PMID 10683250. doi:10.1006/abbi.1999.1589. 
  • Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250. 
  • Kimura T, Watanabe T, Sato K et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.". Biochem. J. 348 Pt 1: 71–6. PMID 10794715. doi:10.1042/0264-6021:3480071. 

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