Prostaglandinski F receptor

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
edit
Prostaglandinski F receptor (FP)
Identifikatori
SimboliPTGFR; FP
Vanjski IDOMIM600563 MGI97796 HomoloGene741 IUPHAR: FP GeneCards: PTGFR Gene
Pregled RNK izražavanja
PBB GE PTGFR 207177 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez573719220
EnsemblENSG00000122420ENSMUSG00000028036
UniProtP43088P43117
RefSeq (mRNA)NM_000959.3NM_008966.3
RefSeq (protein)NP_000950.1NP_032992.1
Lokacija (UCSC)Chr 1:
78.77 - 79.01 Mb
Chr 3:
151.46 - 151.5 Mb
PubMed pretraga[1][2]

Prostaglandinski F receptor (FP) je receptor za prostaglandin F. On je kodiran PTGFR genom.[1]

Ovaj protein je član familije G protein spregnutih receptora.

Dve transkriptne varijante koji kodiraju različite izoforme su nađene za ovaj gen.[1]

Funkcije[uredi - уреди | uredi izvor]

Glavni efekti vezivanja prostaglandina za ovaj receptor su:

Putem aktivacije ovog receptora, PGF2-alfa posreduje luteolizu[1], i može da učestvuje u modulaciji intraokularnog pritiska i kontrakcija glatkih mišića materice i sfinktera gastrointestinalnog trakta[3].

Ispitivanja na nokaut miševima sugeriraju da interakcije PGF2-alfa sa ovim receptorom u lutealnim ćelijama jajnika iniciraju luteolizu i tako indukuju porođaj.[4]

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 1,2 "Entrez Gene: PTGFR prostaglandin F receptor (FP)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737. 
  2. Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 234
  3. Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. Sugimoto Y; Yamasaki A; Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. PMID 9235889. doi:10.1126/science.277.5326.681. 

Literatura[uredi - уреди | uredi izvor]

  • Duncan AM; Anderson LL; Funk CD et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–2. PMID 7759114. doi:10.1016/0888-7543(95)80022-E. 
  • Lake S; Gullberg H; Wahlqvist J et al. (1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor". FEBS Lett. 355 (3): 317–25. PMID 7988697. doi:10.1016/0014-5793(94)01198-2. 
  • Bastien L; Sawyer N; Grygorczyk R et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • Funk CD; Furci L; FitzGerald GA et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
  • Abramovitz M; Boie Y; Nguyen T et al. (1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". J. Biol. Chem. 269 (4): 2632–6. PMID 8300593. 
  • Sugimoto Y; Yamasaki A; Segi E et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. PMID 9235889. doi:10.1126/science.277.5326.681. 
  • Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha". J. Biol. Chem. 272 (43): 27147–54. PMID 9341156. doi:10.1074/jbc.272.43.27147. 
  • Betz R; Lagercrantz J; Kedra D et al. (1999). "Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene". Biochem. Biophys. Res. Commun. 254 (2): 413–6. PMID 9918852. doi:10.1006/bbrc.1998.9827. 
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Neuschäfer-Rube F; Engemaier E; Koch S et al. (2003). "Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor". Biochem. J. 371 (Pt 2): 443–9. PMC 1223288. PMID 12519077. doi:10.1042/BJ20021429. 
  • Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). "Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene". Biochim. Biophys. Acta 1676 (2): 193–202. PMID 14746914. doi:10.1016/j.bbaexp.2003.11.004. 
  • Sales KJ; Milne SA; Williams AR et al. (2004). "Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways". J. Clin. Endocrinol. Metab. 89 (2): 986–93. PMID 14764825. doi:10.1210/jc.2003-031434. 
  • Vielhauer GA, Fujino H, Regan JW (2004). "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor". Arch. Biochem. Biophys. 421 (2): 175–85. PMID 14984197. doi:10.1016/j.abb.2003.10.021. 
  • Jin P; Fu GK; Wilson AD et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics 83 (4): 566–71. PMID 15028279. doi:10.1016/j.ygeno.2003.09.023. 
  • Sugino N; Karube-Harada A; Taketani T et al. (2004). "Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation". J. Reprod. Dev. 50 (2): 215–25. PMID 15118249. doi:10.1262/jrd.50.215. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
  • Scott G; Jacobs S; Leopardi S et al. (2005). "Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation". Exp. Cell Res. 304 (2): 407–16. PMID 15748887. doi:10.1016/j.yexcr.2004.11.016. 
  • Mandal AK; Ray R; Zhang Z et al. (2005). "Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators". J. Biol. Chem. 280 (38): 32897–904. PMID 16061484. doi:10.1074/jbc.M502375200. 
  • Hébert RL, Carmosino M, Saito O et al. (2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.". J. Biol. Chem. 280 (41): 35028–37. PMID 16096282. doi:10.1074/jbc.M505852200. 

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]