GPR35

G protein-spregnuti receptor 35
Identifikatori
Simboli	GPR35;
Vanjski ID	OMIM: 602646 MGI: 1929509 HomoloGene: 3874 IUPHAR: GPR35 GeneCards: GPR35 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

GPR35, G protein-spregnuti receptor 35, je protein koji je kod čoveka kodiran GPR35 genom.^[1] Povišeno izražavanje GPR35 receptora je nađeno u imunskim i gastrointestinalnim tkivima.

Ligandi

Jedna studija je pokazala da kinurenska kiselina deluje kao endogeni ligand ovog receptora.^[2] Za zaprinast, PDE5A inhibitor, je isto tako nađeno da je GPR35 agonist.^[3]

Klinički značaj

Brisanje GPR35 gena može da izazove simptome mentalne retardacije. Ovaj gen je mutiran kod 2q37 monosomije i sindroma 2q37 delecije.^[4] Jedna studija je utvrdila da je GPR35 potencijalni onkogen raka želuca.^[5]

Literatura

↑ O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). „Discovery of three novel G-protein-coupled receptor genes”. Genomics 47 (2): 310–3. DOI:10.1006/geno.1998.5095. PMID 9479505.
↑ Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). „Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35”. J. Biol. Chem. 281 (31): 22021–8. DOI:10.1074/jbc.M603503200. PMID 16754668. free fulltext Arhivirano 2009-02-17 na Wayback Machine-u
↑ Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). „Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35”. FEBS Lett. 580 (21): 5003–8. DOI:10.1016/j.febslet.2006.08.015. PMID 16934253.
↑ Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). „Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype”. Clin. Genet. 66 (6): 537–44. DOI:10.1111/j.1399-0004.2004.00363.x. PMID 15521982.
↑ Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). „Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells”. Cancer Sci. 95 (2): 131–5. DOI:10.1111/j.1349-7006.2004.tb03193.x. PMID 14965362.

[pmid9479505-1] O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). „Discovery of three novel G-protein-coupled receptor genes”. Genomics 47 (2): 310–3. DOI:10.1006/geno.1998.5095. PMID 9479505.

[pmid16754668-2] Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). „Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35”. J. Biol. Chem. 281 (31): 22021–8. DOI:10.1074/jbc.M603503200. PMID 16754668. free fulltext Arhivirano 2009-02-17 na Wayback Machine-u

[pmid16934253-3] Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). „Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35”. FEBS Lett. 580 (21): 5003–8. DOI:10.1016/j.febslet.2006.08.015. PMID 16934253.

[pmid15521982-4] Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). „Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype”. Clin. Genet. 66 (6): 537–44. DOI:10.1111/j.1399-0004.2004.00363.x. PMID 15521982.

[pmid14965362-5] Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). „Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells”. Cancer Sci. 95 (2): 131–5. DOI:10.1111/j.1349-7006.2004.tb03193.x. PMID 14965362.

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