Somatostatinski receptor 5

Somatostatinski receptor 5
Identifikatori
Simboli	SSTR5;
Vanjski ID	OMIM: 182455 MGI: 894282 HomoloGene: 20287 IUPHAR: sst5 GeneCards: SSTR5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost somatostatinskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom; • negativna regulacija ćelijske proliferacije; • glukozna homeostaza; • regulacija sekrecije insulina;
Pregled RNK izražavanja
	podaci
Ortolozi

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Somatostatinski receptor tip 5 je protein koji je kod čoveka kodiran SSTR5 genom.^[1]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva.^[2]

Povezano

Somatostatinski receptor

Reference

↑ Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). „Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization”. Genomics 26 (3): 638–9. DOI:10.1016/0888-7543(95)80195-R. PMID 7607700.
↑ „Entrez Gene: SSTR5 somatostatin receptor 5”.

Literatura

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Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). „Primary structure of the gene encoding rat preprosomatostatin.”. Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. DOI:10.1073/pnas.81.11.3337. PMC 345502. PMID 6145156.
Panetta R, Greenwood MT, Warszynska A, et al. (1994). „Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.”. Mol. Pharmacol. 45 (3): 417–27. PMID 7908405.
O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). „Characterization of cloned human somatostatin receptor SSTR5.”. Mol. Pharmacol. 46 (2): 291–8. PMID 8078491.
Yamada Y, Kagimoto S, Kubota A, et al. (1993). „Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.”. Biochem. Biophys. Res. Commun. 195 (2): 844–52. DOI:10.1006/bbrc.1993.2122. PMID 8373420.
Yamada Y, Stoffel M, Espinosa R, et al. (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518.
Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID 9125122.
Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). „Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.”. J. Clin. Endocrinol. Metab. 82 (6): 1857–62. DOI:10.1210/jc.82.6.1857. PMID 9177396.
de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). „Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.”. Genomics 42 (3): 499–506. DOI:10.1006/geno.1997.4763. PMID 9205124.
Jaïs P, Terris B, Ruszniewski P, et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
Hukovic N, Panetta R, Kumar U, et al. (1998). „The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.”. J. Biol. Chem. 273 (33): 21416–22. DOI:10.1074/jbc.273.33.21416. PMID 9694905.
Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82–90. DOI:10.1210/me.13.1.82. PMID 9892014.
Kumar U, Sasi R, Suresh S, et al. (1999). „Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.”. Diabetes 48 (1): 77–85. DOI:10.2337/diabetes.48.1.77. PMID 9892225.
Rocheville M, Lange DC, Kumar U, et al. (2000). „Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.”. J. Biol. Chem. 275 (11): 7862–9. DOI:10.1074/jbc.275.11.7862. PMID 10713101.
Rocheville M, Lange DC, Kumar U, et al. (2000). „Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.”. Science 288 (5463): 154–7. DOI:10.1126/science.288.5463.154. PMID 10753124.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). „Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.”. Hum. Mol. Genet. 10 (4): 339–52. DOI:10.1093/hmg/10.4.339. PMID 11157797.
Ballarè E, Persani L, Lania AG, et al. (2001). „Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment.”. J. Clin. Endocrinol. Metab. 86 (8): 3809–14. DOI:10.1210/jc.86.8.3809. PMID 11502816.
Pasquali D, Notaro A, Esposito D, et al. (2002). „[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]”. Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
Papotti M, Bongiovanni M, Volante M, et al. (2002). „Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.”. Virchows Arch. 440 (5): 461–75. DOI:10.1007/s00428-002-0609-x. PMID 12021920.

Vanjske veze

„Somatostatin Receptors: sst₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH somatostatin+receptor+5

[pmid7607700-1] Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). „Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization”. Genomics 26 (3): 638–9. DOI:10.1016/0888-7543(95)80195-R. PMID 7607700.

[entrez-2] „Entrez Gene: SSTR5 somatostatin receptor 5”.

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