AGTR1

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Angiotenzinski II receptor, tip 1
Identifikatori
SimboliAGTR1; AG2S; AGTR1A; AGTR1B; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R
Vanjski IDOMIM106165 MGI87964 HomoloGene3556 IUPHAR: AT1 GeneCards: AGTR1 Gene
Pregled RNK izražavanja
PBB GE AGTR1 205357 s at tn.png
PBB GE AGTR1 208016 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez18511607
EnsemblENSG00000144891ENSMUSG00000049115
UniProtP30556Q5SVY5
RefSeq (mRNA)NM_000685NM_177322
RefSeq (protein)NP_000676NP_796296
Lokacija (UCSC)Chr 3:
149.9 - 149.94 Mb
Chr 13:
30.34 - 30.39 Mb
PubMed pretraga[1][2]

AGTR1 (Angiotenzinski II receptor, tip 1, AT1 receptor) je angiotenzinski receptor. On ima simpatomimetičko dejstvo i reguliše sekreciju aldosterona. On je značajan efektor kontrole krvnog pritiska i zapremine u kardiovaskularnom sistemu. Antagonisti angiotenzin II receptora su lekovi za hipertenziju, dijabetesnu nefropatiju i srčanu insuficijenciju. AGTR1 je najbolje istraženi angiotenzinski receptor.

Mehanizam[uredi - уреди | uredi izvor]

Angiotenzinski receptori se aktiviraju vazokonstriktivnim peptidom angiotenzin II. Aktivirani receptor se spreže sa Gq/11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca2+, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.[1]

Reference[uredi - уреди | uredi izvor]

  1. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417–28. PMID 17346243. doi:10.1042/CS20060342. 

Literatura[uredi - уреди | uredi izvor]

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  • Mauzy CA, Hwang O, Egloff AM et al. (1992). "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.". Biochem. Biophys. Res. Commun. 186 (1): 277–84. PMID 1378723. doi:10.1016/S0006-291X(05)80804-6. 
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  • Bergsma DJ, Ellis C, Kumar C et al. (1992). "Cloning and characterization of a human angiotensin II type 1 receptor.". Biochem. Biophys. Res. Commun. 183 (3): 989–95. PMID 1567413. doi:10.1016/S0006-291X(05)80288-8. 
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  • Curnow KM, Pascoe L, Davies E et al. (1996). "Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.". Mol. Endocrinol. 9 (9): 1250–62. PMID 7491117. doi:10.1210/me.9.9.1250. 
  • Marrero MB, Schieffer B, Paxton WG et al. (1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.". Nature 375 (6528): 247–50. PMID 7746328. doi:10.1038/375247a0. 

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