AGTR1

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Angiotenzinski II receptor, tip 1
Identifikatori
SimboliAGTR1; AG2S; AGTR1A; AGTR1B; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R
Vanjski IDOMIM106165 MGI87964 HomoloGene3556 IUPHAR: AT1 GeneCards: AGTR1 Gene
Pregled RNK izražavanja
PBB GE AGTR1 205357 s at tn.png
PBB GE AGTR1 208016 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez18511607
EnsemblENSG00000144891ENSMUSG00000049115
UniProtP30556Q5SVY5
RefSeq (mRNA)NM_000685NM_177322
RefSeq (protein)NP_000676NP_796296
Lokacija (UCSC)Chr 3:
149.9 - 149.94 Mb
Chr 13:
30.34 - 30.39 Mb
PubMed pretraga[1][2]

AGTR1 (Angiotenzinski II receptor, tip 1, AT1 receptor) je angiotenzinski receptor. On ima simpatomimetičko dejstvo i reguliše sekreciju aldosterona. On je značajan efektor kontrole krvnog pritiska i zapremine u kardiovaskularnom sistemu. Antagonisti angiotenzin II receptora su lekovi za hipertenziju, dijabetesnu nefropatiju i srčanu insuficijenciju. AGTR1 je najbolje istraženi angiotenzinski receptor.

Mehanizam[uredi | uredi kod]

Angiotenzinski receptori se aktiviraju vazokonstriktivnim peptidom angiotenzin II. Aktivirani receptor se spreže sa Gq/11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca2+, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.[1]

Reference[uredi | uredi kod]

  1. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). „Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology”. Clin. Sci. 112 (8): 417–28. DOI:10.1042/CS20060342. PMID 17346243. 

Literatura[uredi | uredi kod]

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  • Stowasser M, Gunasekera TG, Gordon RD (2002). „Familial varieties of primary aldosteronism.”. Clin. Exp. Pharmacol. Physiol. 28 (12): 1087–90. DOI:10.1046/j.1440-1681.2001.03574.x. PMID 11903322. 
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  • Elton TS, Martin MM (2003). „Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor.”. Trends Endocrinol. Metab. 14 (2): 66–71. DOI:10.1016/S1043-2760(02)00038-3. PMID 12591176. 
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  • Ariza AC, Bobadilla NA, Halhali A (2007). „[Endothelin 1 and angiotensin II in preeeclampsia]”. Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
  • Xia Y, Zhou CC, Ramin SM, Kellems RE (2007). „Angiotensin receptors, autoimmunity, and preeclampsia.”. J. Immunol. 179 (6): 3391–5. PMID 17785770. 
  • Mauzy CA, Hwang O, Egloff AM, et al. (1992). „Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.”. Biochem. Biophys. Res. Commun. 186 (1): 277–84. DOI:10.1016/S0006-291X(05)80804-6. PMID 1378723. 
  • Curnow KM, Pascoe L, White PC (1992). „Genetic analysis of the human type-1 angiotensin II receptor.”. Mol. Endocrinol. 6 (7): 1113–8. DOI:10.1210/me.6.7.1113. PMID 1508224. 
  • Furuta H, Guo DF, Inagami T (1992). „Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (1): 8–13. DOI:10.1016/0006-291X(92)91600-U. PMID 1543512. 
  • Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). „Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 183 (2): 910–6. DOI:10.1016/0006-291X(92)90570-B. PMID 1550596. 
  • Bergsma DJ, Ellis C, Kumar C, et al. (1992). „Cloning and characterization of a human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (3): 989–95. DOI:10.1016/S0006-291X(05)80288-8. PMID 1567413. 
  • Gemmill RM, Drabkin HA (1992). „Report of the Second International Workshop on Human Chromosome 3 mapping.”. Cytogenet. Cell Genet. 57 (4): 162–6. PMID 1683828. 
  • Curnow KM, Pascoe L, Davies E, et al. (1996). „Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.”. Mol. Endocrinol. 9 (9): 1250–62. DOI:10.1210/me.9.9.1250. PMID 7491117. 
  • Marrero MB, Schieffer B, Paxton WG, et al. (1995). „Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.”. Nature 375 (6528): 247–50. DOI:10.1038/375247a0. PMID 7746328. 

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