TAS2R31
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| Receptor ukusa tip 2 član 31 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R31; T2R31; T2R44; T2R53; TAS2R44 | ||||||||||
| Vanjski ID | OMIM: 612669 MGI: 2681304 HomoloGene: 89249 IUPHAR: GeneCards: TAS2R31 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 259290 | 353165 | |||||||||
| Ensembl | ENSG00000256436 | ENSMUSG00000053217 | |||||||||
| UniProt | P59538 | Q7TQA8 | |||||||||
| RefSeq (mRNA) | NM_176885.2 | NM_181276.1 | |||||||||
| RefSeq (protein) | NP_795366.2 | NP_851793.1 | |||||||||
| Lokacija (UCSC) | Chr 12: 11.18 - 11.18 Mb | Chr 6: 132.73 - 132.73 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 31 je protein koji je kod ljudi kodiran TAS2R31 genom.[1] Ovaj receptor gorkog ukusa proizvodi respons pri izlaganju saharinu in vitro.[2]
TAS2R31 je takođe izražen u glatkim mišićima ljudskih vazdušnih puteva, zajedno sa nekoliko drugih receptora ukusa. Njihova aktivacija u tim ćelijama uzrokuje povišenje nivoa intracelularnih jona kalcijuma, koje zatim podstiče otvaranje kalijumskih kanala čime se hiperpolarizuje membrana i dolazi do relaksacije glatkih mišića. Iz tog razloga, aktivacija ovih receptora dovodi do bronhodilatacije.[3]
Reference[uredi | uredi kod]
- ↑ „Entrez Gene: TAS2R31 taste receptor, type 2, member 31”.
- ↑ Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (November 2004). „Bitter taste receptors for saccharin and acesulfame K”. J. Neurosci. 24 (45): 10260–5. DOI:10.1523/JNEUROSCI.1225-04.2004. PMID 15537898.
- ↑ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). „Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction”. Nat. Med. 16 (11): 1299–304. DOI:10.1038/nm.2237. PMC 3066567. PMID 20972434.
Literatura[uredi | uredi kod]
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Conte C, Ebeling M, Marcuz A, et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family.”. Cytogenet. Genome Res. 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440.
- Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors.”. Chem. Senses 29 (7): 583–93. DOI:10.1093/chemse/bjh064. PMID 15337684.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
- Kuhn C, Bufe B, Winnig M, et al. (2005). „Bitter taste receptors for saccharin and acesulfame K.”. J. Neurosci. 24 (45): 10260–5. DOI:10.1523/JNEUROSCI.1225-04.2004. PMID 15537898.