GPR143

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G protein-coupled receptor 143
Identifikatori
SimboliGPR143; NYS6; OA1
Vanjski IDOMIM300808 MGI107193 HomoloGene230 IUPHAR: GPR143 GeneCards: GPR143 Gene
Pregled RNK izražavanja
PBB GE GPR143 206696 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez493518241
EnsemblENSG00000101850ENSMUSG00000025333
UniProtP51810P70259
RefSeq (mRNA)NM_000273.2NM_010951.3
RefSeq (protein)NP_000264.2NP_035081.3
Lokacija (UCSC)Chr X:
9.69 - 9.75 Mb
Chr X:
149.22 - 149.24 Mb
PubMed pretraga[1][2]
Okularni albinizam tip 1 protein
Identifikatori
Simbol Ocular_alb
Pfam PF02101
Pfam klan CL0192
InterPro IPR001414

G protein spregnuti receptor 143 je protein koji je kod ljudi kodiran GPR143 genom.[1][2][3]

Okularni albinizam tip 1 protein je konzervirani integralni membranski protein sa sedam transmembranskih domena. On je izražen u oku i epidermalnim melanocitima.[3]

GPR143 gen je regulisan mikroftalmija-asociranim transkripcionim faktorom.[4][5]

L-DOPA je endogeni ligand za OA1.[6]

Interakcije[uredi - уреди | uredi izvor]

GPR143 formira initekcije Protein-protein interakcija sa GNAI1.[7]

Reference[uredi - уреди | uredi izvor]

  1. Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet 10 (1): 13–9. PMID 7647783. doi:10.1038/ng0595-13.  Check date values in: |date= (help)
  2. Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet 23 (1): 108–12. PMID 10471510. doi:10.1038/12715.  Check date values in: |date= (help)
  3. 3,0 3,1 "Entrez Gene: GPR143 G protein-coupled receptor 143". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4935. 
  4. Vetrini F, Auricchio A, Du J et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. PMC 444869. PMID 15254223. doi:10.1128/MCB.24.15.6550-6559.2004. 
  5. Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 
  6. Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh, Gregory S., ed. "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. PMC 2553842. PMID 18828673. doi:10.1371/journal.pbio.0060236. 
  7. Schiaffino, M V; d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi M T, Colla C, De Luca M, Tacchetti C, Ballabio A (September 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat. Genet. (UNITED STATES) 23 (1): 108–12. ISSN 1061-4036. PMID 10471510. doi:10.1038/12715. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]