GPR182

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G protein spregnuti receptor 182
Identifikatori
SimboliGPR182; 7TMR; AMR; MGC34399; gamrh; hrhAMR
Vanjski IDOMIM605307 MGI109545 HomoloGene5255 IUPHAR: GPR182 GeneCards: GPR182 Gene
Pregled RNK izražavanja
PBB GE ADMR 214506 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez1131811536
EnsemblENSG00000166856n/a
UniProtO15218n/a
RefSeq (mRNA)NM_007264NM_007412
RefSeq (protein)NP_009195NP_031438
Lokacija (UCSC)Chr 12:
55.67 - 55.68 Mb
n/a
PubMed pretraga[1][2]

GPR182 (ili G protein spregnuti receptor 182) je ljudski gen (i asocirani protein) koji je orfan GPCR.[1]

Kad je ovaj gen bio kloniran prvi put, pretpostavljeno je da kodira adrenomedulin receptor.[2] Međutim kad je korespondirajući protein izražen, utvrđeno je da ne proizvodi respons na adrenomedulin (ADM).[3]

Naknadno je bilo pokazano da jedan drugi GPCR receptor, CALCRL u kompleksu sa RAMP2 može da funkcioniše kao ADM receptor.[4]

Literatura[uredi - уреди | uredi izvor]

  1. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. PMC 153653. PMID 12679517. doi:10.1073/pnas.0230374100. 
  2. Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–8. PMID 9367907. doi:10.1006/bbrc.1997.7631. 
  3. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–7. PMID 9535752. doi:10.1006/bbrc.1998.8349. 
  4. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. PMID 9620797. doi:10.1038/30666. 

Dodatna literatura[uredi - уреди | uredi izvor]

  • Lah JJ, Frishman WH (2002). "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential.". Heart disease (Hagerstown, Md.) 2 (3): 259–65. PMID 11728267. 
  • Mukoyama M, Sugawara A, Nagae T et al. (2002). "Role of adrenomedullin and its receptor system in renal pathophysiology.". Peptides 22 (11): 1925–31. PMID 11754983. doi:10.1016/S0196-9781(01)00525-3. 
  • Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).". Int. J. Mol. Med. 9 (5): 443–9. PMID 11956648. 
  • Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells.". Eur. J. Pharmacol. 289 (2): 383–5. PMID 7621913. doi:10.1016/0922-4106(95)90117-5. 
  • Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). "Adrenomedullin receptor expression in human lung and in pulmonary tumors.". J. Histochem. Cytochem. 45 (2): 159–64. PMID 9016306. 
  • Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.". Biochem. Biophys. Res. Commun. 240 (1): 183–8. PMID 9367907. doi:10.1006/bbrc.1997.7631. 
  • Martínez A, Elsasser TH, Muro-Cacho C et al. (1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument.". Endocrinology 138 (12): 5597–604. PMID 9389548. doi:10.1210/en.138.12.5597. 
  • Kennedy SP, Sun D, Oleynek JJ et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.". Biochem. Biophys. Res. Commun. 244 (3): 832–7. PMID 9535752. doi:10.1006/bbrc.1998.8349. 
  • Jiménez N, Calvo A, Martínez A et al. (1999). "Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate.". J. Histochem. Cytochem. 47 (9): 1167–78. PMID 10449538. 
  • Kuwasako K, Kitamura K, Ito K et al. (2002). "The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors.". J. Biol. Chem. 276 (52): 49459–65. PMID 11591721. doi:10.1074/jbc.M108369200. 
  • Forneris M, Gottardo L, Albertin G et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.". Int. J. Mol. Med. 8 (6): 675–9. PMID 11712085. 
  • Hänze J, Groneberg DA, Rose F et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.". Biochem. Biophys. Res. Commun. 291 (5): 1160–5. PMID 11883938. doi:10.1006/bbrc.2002.6595. 
  • Dumont CE, Muff R, Flühmann B et al. (2003). "Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.". Brain Res. 955 (1-2): 64–71. PMID 12419522. doi:10.1016/S0006-8993(02)03365-6. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Chosa E, Hamada H, Kitamura K et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.". Biochem. Biophys. Res. Commun. 303 (1): 379–86. PMID 12646214. doi:10.1016/S0006-291X(03)00347-4. 
  • Xu P, Dai AG, Zhou HD et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi 26 (12): 765–8. PMID 14720432. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 

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