GNRHR2

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Gonadotropin-oslobađajući hormonski receptor II
Identifikatori
SimboliGNRHR2; GnRH-II-R
Vanjski IDIUPHAR: GnRH2 GeneCards: GNRHR2 Gene
Ortolozi
VrstaČovekMiš
Entrez114814n/a
EnsemblENSG00000211451n/a
UniProtQ96P88n/a
RefSeq (mRNA)NR_002328n/a
RefSeq (protein)n/an/a
Lokacija (UCSC)Chr 1:
145.51 - 145.52 Mb
n/a
PubMed pretraga[1]n/a

GNRHR2, gonadotropin-oslobađajući hormonski receptor II, je protein koji je kod ljudi kodiran GNRHR2 genom.[1][2]

Receptor gonadotropin oslobađajućeg hormona 2 (GnRH2) je G protein spregnuti receptor, koji je kodiran GnRHR2 genom kod ne-hominoidnih primata i ne-sisarskih kičmenjaka. Kod ljudi, N-terminus protein ima pomeranje okvira čitanja sekvence i prerani stop kodon. Mada dolazi do transkripcije, još uvek nije potpuno razjašnjeno da li je receptor funkcionalan. Alternativne splajsne varijante su poznate. Nentranskribovani GnRHR2 pseudogen takođe postoji na hromozomu 14.[2]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics 78 (1–2): 15–8. DOI:10.1006/geno.2001.6650. PMID 11707068. 
  2. 2,0 2,1 "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814. 

Literatura[uredi - уреди | uredi izvor]

  • Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology 143 (3): 737–43. DOI:10.1210/en.143.3.737. PMID 11861490. 
  • Millar R, Conklin D, Lofton-Day C, et al. (1999). "A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript". J. Endocrinol. 162 (1): 117–26. DOI:10.1677/joe.0.1620117. PMID 10396028. 
  • Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates". Biochem. Biophys. Res. Commun. 282 (4): 1012–8. DOI:10.1006/bbrc.2001.4678. PMID 11352653. 
  • van Biljon W, Wykes S, Scherer S, et al. (2003). "Type II gonadotropin-releasing hormone receptor transcripts in human sperm". Biol. Reprod. 67 (6): 1741–9. DOI:10.1095/biolreprod.101.002808. PMID 12444048. 
  • Morgan K, Conklin D, Pawson AJ, et al. (2003). "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12". Endocrinology 144 (2): 423–36. DOI:10.1210/en.2002-220622. PMID 12538601. 
  • Pawson AJ, Maudsley S, Morgan K, et al. (2005). "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology 146 (6): 2639–49. DOI:10.1210/en.2005-0133. PMID 15761034. 
  • Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. DOI:10.1530/eje.1.02005. PMID 16189182. 
  • Ikemoto T, Park MK (2006). "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics 87 (4): 459–62. DOI:10.1016/j.ygeno.2005.11.005. PMID 16406723. 
  • Parker JD, Malik M, Catherino WH (2007). "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. DOI:10.1016/j.fertnstert.2006.11.098. PMID 17296196. 

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