C3a receptor

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Receptor 1 komplementne komponente 3a
Identifikatori
Simboli C3AR1; AZ3B; C3AR; HNFAG09
Vanjski ID OMIM605246 MGI1097680 HomoloGene2992 IUPHAR: C3a GeneCards: C3AR1 Gene
Pregled RNK izražavanja
PBB GE C3AR1 209906 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 719 12267
Ensembl ENSG00000171860 ENSMUSG00000040552
UniProt Q16581 Q3U4N3
RefSeq (mRNA) NM_004054 NM_009779
RefSeq (protein) NP_004045 NP_033909
Lokacija (UCSC) Chr 12:
8.1 - 8.11 Mb
Chr 6:
122.81 - 122.82 Mb
PubMed pretraga [1] [2]

C3a receptor (receptor 1 komplementne komponente 3a, C3AR1) je G protein-spregnuti receptor koji je deo sistema komplementa.[1][2]

Ligandi ovog receptora su C3a i C4a.

Literatura[uredi - уреди | uredi izvor]

  1. Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247. 
  2. Ali H, Panettieri RA (2005). "Anaphylatoxin C3a receptors in asthma". Respir. Res. 6: 19. PMC 551592. PMID 15723703. doi:10.1186/1465-9921-6-19. 

Dodatna literatura[uredi - уреди | uredi izvor]

  • Sim RB, Laich A (2001). "Serine proteases of the complement system". Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Roglic A, Prossnitz ER, Cavanagh SL et al. (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247. 
  • Ames RS, Li Y, Sarau HM et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". J. Biol. Chem. 271 (34): 20231–4. PMID 8702752. doi:10.1074/jbc.271.34.20231. 
  • Crass T, Raffetseder U, Martin U et al. (1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". Eur. J. Immunol. 26 (8): 1944–50. PMID 8765043. doi:10.1002/eji.1830260840. 
  • Ames RS, Nuthulaganti P, Kumar C (1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Lett. 395 (2–3): 157–9. PMID 8898085. doi:10.1016/0014-5793(96)01018-6. 
  • Martin U, Bock D, Arseniev L et al. (1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". J. Exp. Med. 186 (2): 199–207. PMC 2198980. PMID 9221749. doi:10.1084/jem.186.2.199. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Hollmann TJ, Haviland DL, Kildsgaard J et al. (1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Mol. Immunol. 35 (3): 137–48. PMID 9694514. doi:10.1016/S0161-5890(98)00021-2. 
  • Lienenklaus S, Ames RS, Tornetta MA et al. (1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". J. Immunol. 161 (5): 2089–93. PMID 9725198. 
  • Davoust N, Jones J, Stahel PF et al. (1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia 26 (3): 201–11. PMID 10340761. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. 
  • Settmacher B, Bock D, Saad H et al. (1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". J. Immunol. 162 (12): 7409–16. PMID 10358194. 
  • Feild JA, Foley JJ, Testa TT et al. (1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Lett. 460 (1): 53–6. PMID 10571060. doi:10.1016/S0014-5793(99)01317-4. 
  • Petering H, Köhl J, Weyergraf A et al. (2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". J. Immunol. 164 (7): 3783–9. PMID 10725738. 
  • Drouin SM, Kildsgaard J, Haviland J et al. (2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". J. Immunol. 166 (3): 2025–32. PMID 11160252. 
  • Ames RS, Lee D, Foley JJ et al. (2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". J. Immunol. 166 (10): 6341–8. PMID 11342658. 
  • Kirchhoff K, Weinmann O, Zwirner J et al. (2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology 103 (2): 210–7. PMC 1783227. PMID 11412308. doi:10.1046/j.1365-2567.2001.01197.x. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Reca R, Mastellos D, Majka M et al. (2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood 101 (10): 3784–93. PMID 12511407. doi:10.1182/blood-2002-10-3233. 

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