S1PR1

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
edit
Sfingozin-1-fosfatni receptor 1

Struktura SIPR1-lizozim fuzije 3v2y[1]
Dostupne strukture
3V2W, 3V2Y
Identifikatori
SimboliS1PR1; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1
Vanjski IDOMIM601974 MGI1096355 HomoloGene1071 IUPHAR: S1P1 GeneCards: S1PR1 Gene
Pregled RNK izražavanja
PBB GE EDG1 204642 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez190113609
EnsemblENSG00000170989ENSMUSG00000045092
UniProtP21453O08530
RefSeq (mRNA)NM_001400.4NM_007901.5
RefSeq (protein)NP_001391.2NP_031927.2
Lokacija (UCSC)Chr 1:
101.7 - 101.71 Mb
Chr 3:
115.41 - 115.42 Mb
PubMed pretraga[1][2]

S1PR1 (sfingozin-1-fosfatni receptor 1, S1P1, EDG1, endotelni diferencijacioni gen 1) je protein koji je kod ljudi kodiran S1PR1 genom. S1P1 je G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin-1-fosfat (S1P).

Funkcija[uredi - уреди | uredi izvor]

Ovaj protein je visoko izražen u endotelnim ćelijama. On vezuje sfingozin-1-fosfat sa visokim afinitetom i specifičnošću, i smatra se da učestvuje u procesima koji regulišu diferencijaciju endotelnih ćelija. Aktivacija ovog receptora indukuje međućelijsku adheziju.[2]

Interakcije[uredi - уреди | uredi izvor]

S1PR1 formira interakcije sa 5-HT1A receptorom,[3] GNAI1[4] i GNAI3.[4]

Reference[uredi - уреди | uredi izvor]

  1. Hanson, M. A.; Roth, C. B.; Jo, E.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S. M. (2012). "Crystal Structure of a Lipid G Protein-Coupled Receptor". Science 335 (6070): 851. doi:10.1126/science.1215904. 
  2. "Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1901. 
  3. Salim, Kamran; Fenton Tim, Bacha Jamil, Urien-Rodriguez Hector, Bonnert Tim, Skynner Heather A, Watts Emma, Kerby Julie, Heald Anne, Beer Margaret, McAllister George, Guest Paul C (May 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. (United States) 277 (18): 15482–5. ISSN 0021-9258. PMID 11854302. doi:10.1074/jbc.M201539200. 
  4. 4,0 4,1 Lee, M J; Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272. 

Literatura[uredi - уреди | uredi izvor]

  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x. 
  • Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476–9. PMID 11915345. 
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348. 
  • Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.". J. Biochem. 131 (6): 767–71. PMID 12038970. 
  • Wang D, Zhao Z, Caperell-Grant A et al. (2008). "S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.". Mol Cancer Ther 7 (7): 1993–2002. PMID 18645009. 
  • Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972. 
  • Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272–9. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • An S, Bleu T, Huang W et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. PMID 9409733. doi:10.1016/S0014-5793(97)01301-X. 
  • Lee MJ, Van Brocklyn JR, Thangada S et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.". Science 279 (5356): 1552–5. PMID 9488656. doi:10.1126/science.279.5356.1552. 
  • Lee MJ, Thangada S, Liu CH et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.". J. Biol. Chem. 273 (34): 22105–12. PMID 9705355. doi:10.1074/jbc.273.34.22105. 
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399. doi:10.1074/jbc.274.27.18997. 
  • Windh RT, Lee MJ, Hla T et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065. doi:10.1074/jbc.274.39.27351. 
  • Lee MJ, Thangada S, Claffey KP et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. PMID 10555146. doi:10.1016/S0092-8674(00)81661-X. 
  • Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.". J. Biol. Chem. 275 (41): 32363–70. PMID 10921915. doi:10.1074/jbc.M003075200. 
  • Parrill AL, Wang D, Bautista DL et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.". J. Biol. Chem. 275 (50): 39379–84. PMID 10982820. doi:10.1074/jbc.M007680200. 
  • Liu Y, Wada R, Yamashita T et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.". J. Clin. Invest. 106 (8): 951–61. PMC 314347. PMID 11032855. doi:10.1172/JCI10905. 
  • Murphy WJ, Eizirik E, Johnson WE et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. PMID 11214319. doi:10.1038/35054550. 
  • Hobson JP, Rosenfeldt HM, Barak LS et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.". Science 291 (5509): 1800–3. PMID 11230698. doi:10.1126/science.1057559. 
  • Lee MJ, Thangada S, Paik JH et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.". Mol. Cell 8 (3): 693–704. PMID 11583630. doi:10.1016/S1097-2765(01)00324-0. 

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]