Receptor gastričnog inhibitornog polipeptida

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Receptor gastričnog inhibitornog polipeptida‎
Dostupne strukture
2QKH
Identifikatori
SimboliGIPR; PGQTL2
Vanjski IDOMIM137241 MGI1352753 HomoloGene20081 IUPHAR: GIP GeneCards: GIPR Gene
Pregled RNK izražavanja
PBB GE GIPR 208105 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez2696381853
EnsemblENSG00000010310ENSMUSG00000030406
UniProtP48546Q0P543
RefSeq (mRNA)NM_000164.2NM_001080815.1
RefSeq (protein)NP_000155.1NP_001074284.1
Lokacija (UCSC)Chr 19:
46.17 - 46.19 Mb
Chr 7:
19.74 - 19.75 Mb
PubMed pretraga[1][2]

Receptor gastričnog inhibitornog polipeptida (GIP-R, glukozno zavisni insulinotropni polipeptidni receptor) je protein koji je kod ljudi kodiran GIPR genom.[1][2] GIP-R je sedam transmembranski protein prisutan u beta ćelijama u pancreasu.[3][4]

Funkcija[uredi - уреди | uredi izvor]

Gastrični inhibitorni polipeptid (GIP, glukozno zavisni insulinotropni polipeptid) je 42 aminokiseline dug polipeptid koji sintetišu K ćelije dvanaestopalačnog i tankih creva. On je originalno identifikovan kao sastojak stomačnog ekstrakta koji inhibira sekreciju želudačne kiseline i oslobađanje gastrina, ali je naknadno pokazano da potentno stimuliše otpuštanje insulina u prisustvu povišenih nivoa glukoze. Insulinotropno dejstvo na pankreasne beta ćelije je stoga njegova glavna fiziološka uloga. Zajedno sa glukagonu sličnim peptidom-1, GIP je u velikoj meri odgovoran za sekreciju insulina nakon jela. On učestvuje u nekoliko različitih oblika anaboličkog otpuštaja.[1]

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 "Entrez Gene: gastric inhibitory polypeptide receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2696. 
  2. Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics 28 (3): 607–609. PMID 7490109. doi:10.1006/geno.1995.1203. 
  3. "Gastrointestinal Hormones and Peptides". http://web.indstate.edu/thcme/mwking/peptide-hormones.html#gastrin. pristupljeno 24. 08. 2007.. 
  4. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels 8 (3–4): 179–188. PMID 12529935. doi:10.1080/10606820213687. 

Literatura[uredi - уреди | uredi izvor]

  • Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice". Horm. Metab. Res. 36 (11–12): 771–774. PMID 15655707. doi:10.1055/s-2004-826162. 
  • Gremlich S; Porret A; Hani EH et al. (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor". Diabetes 44 (10): 1202–1208. PMID 7556958. doi:10.2337/diabetes.44.10.1202. 
  • Volz A; Göke R; Lankat-Buttgereit B et al. (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma". FEBS Lett. 373 (1): 23–29. PMID 7589426. doi:10.1016/0014-5793(95)01006-Z. 
  • Usdin TB; Mezey E; Button DC et al. (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain". Endocrinology 133 (6): 2861–2870. PMID 8243312. doi:10.1210/en.133.6.2861. 
  • Yamada Y; Hayami T; Nakamura K et al. (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA". Genomics 29 (3): 773–776. PMID 8575774. doi:10.1006/geno.1995.9937. 
  • Gallwitz B; Witt M; Morys-Wortmann C et al. (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". Regul. Pept. 63 (1): 17–22. PMID 8795084. doi:10.1016/0167-0115(96)00019-5. 
  • N'Diaye N; Tremblay J; Hamet P et al. (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome". J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. PMID 9709947. doi:10.1210/jc.83.8.2781. 
  • Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling". Endocrinology 141 (3): 947–952. PMID 10698169. doi:10.1210/en.141.3.947. 
  • Bollag RJ; Zhong Q; Phillips P et al. (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors". Endocrinology 141 (3): 1228–1235. PMID 10698200. doi:10.1210/en.141.3.1228. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Baldacchino V; Oble S; Hamet P et al. (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene". Endocr. Res. 28 (4): 577–577. PMID 12530665. doi:10.1081/ERC-120016843. 
  • Antonini SR; N'Diaye N; Hamet P et al. (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)". Endocr. Res. 28 (4): 755–756. PMID 12530694. doi:10.1081/ERC-120017003. 
  • Manhart S; Hinke SA; McIntosh CH et al. (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers". Biochemistry 42 (10): 3081–3088. PMID 12627975. doi:10.1021/bi026868e. 
  • Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. PMID 12721154. doi:10.1152/ajpendo.00509.2002. 
  • Grimwood J; Gordon LA; Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–535. PMID 15057824. doi:10.1038/nature02399. 
  • Hansotia T; Baggio LL; Delmeire D et al. (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors". Diabetes 53 (5): 1326–1335. PMID 15111503. doi:10.2337/diabetes.53.5.1326. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
  • Baldacchino V; Oble S; Hamet P et al. (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter". Endocr. Res. 30 (4): 805–806. PMID 15666829. doi:10.1081/ERC-200044046. 

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