Cisteinil leukotrienski receptor 1

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Cisteinil leukotrienski receptor 1
Identifikatori
SimboliCYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81
Vanjski IDOMIM300201 MGI1926218 HomoloGene4837 IUPHAR: CysLT1 GeneCards: CYSLTR1 Gene
Ortolozi
VrstaČovekMiš
Entrez1080058861
EnsemblENSG00000173198ENSMUSG00000052821
UniProtQ9Y271Q99JA4
RefSeq (mRNA)NM_006639.2NM_021476.4
RefSeq (protein)NP_006630.1NP_067451.2
Lokacija (UCSC)Chr X:
77.53 - 77.58 Mb
Chr X:
103.77 - 103.8 Mb
PubMed pretraga[1][2]

Cisteinil leukotrienski receptor 1 je protein koji je kod ljudi kodiran CYSLTR1 genom.[1][2][3]

Cisteinil leukotrieni LTC4, LTD4 i LTE4 su posrednici ljudske bronhijalne astme. Farmakološke studije su utvrdile da cisteinil leukotrieni aktiviraju najmanje 2 receptora, protein kodiran ovim genom i CYSLTR2. Ovaj receptor je član superfamilije G protein spregnutih receptora. Aktivacija ovog receptora LTD4 ligandom dovodi kontrakcija i proliferacije glatkih mišića, eozinofilne migracije i oštećenja sluznog sloja pluća.[3]

Reference[uredi - уреди | uredi izvor]

  1. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). "Characterization of the human cysteinyl leukotriene CysLT1 receptor". Nature 399 (6738): 789–93. PMID 10391245. doi:10.1038/21658.  Check date values in: |date= (help)
  2. Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor". Mol Pharmacol 56 (3): 657–63. PMID 10462554.  Check date values in: |date= (help)
  3. 3,0 3,1 "Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10800. 

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