Neuromedinski U receptor
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Neuromedinski U receptori su G protein spregnuti receptori koji vezuju neuropeptidne hormone neuromedin U i neuromedin S.[1] Postoje dva tipa neuromedin U receptora, koji su kodirani zasebnim genima (NMUR1, NMUR2).
Selektivni ligandi[uredi | uredi kod]
Neuromedin U je agonist NMU1 i NMU2 tipa, dok je neuromedin S selektivan za NMU2, i on je potentniji agonist od neuromedina U.[2][3] Nekoliko drugih peptidnih i ne-peptidnih liganda NMU receptora je takođe poznato.
Agonisti[uredi | uredi kod]
- Neselektivni
- Neuromedin U
- ne-peptidni NMU modulatori[4][5]
- NMU2 selektivni
Antagonisti[uredi | uredi kod]
- NMU2 selectivni
- R-PSOP[6]
Literatura[uredi | uredi kod]
- ↑ Brighton PJ, Szekeres PG, Willars GB (June 2004). „Neuromedin U and its receptors: structure, function, and physiological roles”. Pharmacological Reviews 56 (2): 231–48. DOI:10.1124/pr.56.2.3. PMID 15169928.
- ↑ Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756.
- ↑ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999.
- ↑ Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW (April 2008). „Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay”. Acta Pharmacologica Sinica 29 (4): 517–27. DOI:10.1111/j.1745-7254.2008.00769.x. PMID 18358099.
- ↑ Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
- ↑ Liu JJ, Payza K, Huang J, Liu R, Chen T, Coupal M, Laird JM, Cao CQ, Butterworth J, Lapointe S, Bayrakdarian M, Trivedi S, Bostwick JR (July 2009). „Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2”. The Journal of Pharmacology and Experimental Therapeutics 330 (1): 268–75. DOI:10.1124/jpet.109.152967. PMID 19369576.
Spoljašnje veze[uredi | uredi kod]
- „Neuromedin U Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- MeSH Neuromedin+U+Receptor