Neuropeptidni B/W receptor 2
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| Neuropeptidni B/W receptor 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | NPBWR2; GPR8 | ||||||||||
| Vanjski ID | OMIM: 600731 HomoloGene: 48336 IUPHAR: NPBW2 GeneCards: NPBWR2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2832 | n/a | |||||||||
| Ensembl | ENSG00000125522 | n/a | |||||||||
| UniProt | P48146 | n/a | |||||||||
| RefSeq (mRNA) | NM_005286 | n/a | |||||||||
| RefSeq (protein) | NP_005277 | n/a | |||||||||
| Lokacija (UCSC) | Chr 20: 62.21 - 62.21 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Neuropeptidni B/W receptor 2 (NPBW2) je humani protein kodiran NPBWR2 genom.[1]
Ovaj protein je integralni membranski protein i G protein-spregnuti receptor. Njegova sekvenca je slična GPR7 receptoru. On je strukturno sličan opioidnim i somatostatinskim receptorima. Ovaj protein vezuje neuropeptide B i W. Ovaj gen ne sadrži introne. Prvenstveno je izražen u frontalnom korteksu mozga.[1]
Vidi još[uredi | uredi kod]
Literatura[uredi | uredi kod]
Dodatna literatura[uredi | uredi kod]
- O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). „The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.”. Genomics 28 (1): 84–91. DOI:10.1006/geno.1995.1109. PMID 7590751.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Shimomura Y, Harada M, Goto M, et al. (2002). „Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 277 (39): 35826–32. DOI:10.1074/jbc.M205337200. PMID 12130646.
- Brezillon S, Lannoy V, Franssen JD, et al. (2003). „Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 278 (2): 776–83. DOI:10.1074/jbc.M206396200. PMID 12401809.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tanaka H, Yoshida T, Miyamoto N, et al. (2003). „Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.”. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. DOI:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
- Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). „G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.”. J. Clin. Endocrinol. Metab. 90 (6): 3466–71. DOI:10.1210/jc.2004-2132. PMID 15797961.
Spoljašnje veze[uredi | uredi kod]
- „Neuropeptide B/W Receptors: NPBW2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.