LPAR1

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Receptor lizofosfatidne kiseline 1
Identifikatori
SimboliLPAR1; EDG2; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1
Vanjski IDOMIM602282 MGI108429 HomoloGene1072 IUPHAR: LPA1 GeneCards: LPAR1 Gene
Pregled RNK izražavanja
PBB GE EDG2 204038 s at tn.png
PBB GE EDG2 204036 at tn.png
PBB GE EDG2 204037 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez190214745
EnsemblENSG00000198121ENSMUSG00000038668
UniProtQ92633P61793
RefSeq (mRNA)NM_001401.3NM_010336.2
RefSeq (protein)NP_001392.2NP_034466.2
Lokacija (UCSC)Chr 9:
113.64 - 113.8 Mb
Chr 4:
58.45 - 58.57 Mb
PubMed pretraga[1][2]

Receptor lizofosfatidne kiseline 1 (LPA1) je protein koji je kod ljudi kodiran LPAR1 genom.[1][2][3] LPA1 je G protein spregnuti receptor za koji se vezuje lipidni signalni molekul lizofosfatidna kiselina (LPA).[4]

Funkcija[uredi - уреди | uredi izvor]

Integralni membranski protein kodiran ovim genom pripada grupi EDG receptora. Ti receptori su članovi familije G protein spregnutih receptora. EDG receptori posreduju različite bioločkie funkcije, uključujući proliferaciju, agregaciju trombocita, kontrakcije glatkih mišića, inhibiciju diferencijaciju neuroblastomnih ćelija, hemotaksu, i invaziju tumornih ćelija. Alternativno splajsovanje ovog gena je uočeno i dve transkriptne varijante su opisane. One kodiraju identične proteine.[1]

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902. 
  2. Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. PMC 2133395. PMID 8922387. doi:10.1083/jcb.135.4.1071. 
  3. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. PMID 9070858. doi:10.1006/bbrc.1997.6150. 
  4. Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753. 

Literatura[uredi - уреди | uredi izvor]

  • An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.". J. Cell. Biochem. Suppl. 30-31: 147–57. PMID 9893266. 
  • Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753. 
  • Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses.". Curr. Opin. Cell Biol. 9 (2): 168–73. PMID 9069262. doi:10.1016/S0955-0674(97)80059-2. 
  • Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. PMC 27607. PMID 9600933. doi:10.1073/pnas.95.11.6151. 
  • An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623. 
  • Cervera P, Tirard M, Barron S et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1).". Glia 38 (2): 126–36. PMID 11948806. doi:10.1002/glia.10054. 
  • Hama K, Bandoh K, Kakehi Y et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1-3): 187–92. PMID 12123830. doi:10.1016/S0014-5793(02)02976-9. 
  • Van Leeuwen FN, Olivo C, Grivell S et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.". J. Biol. Chem. 278 (1): 400–6. PMID 12393875. doi:10.1074/jbc.M210151200. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.". J. Cell. Sci. 116 (Pt 10): 1969–80. PMID 12668728. doi:10.1242/jcs.00397. 
  • Shida D, Kitayama J, Yamaguchi H et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.". Cancer Res. 63 (7): 1706–11. PMID 12670925. 
  • Matsuda A, Suzuki Y, Honda G et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406. 
  • Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. PMID 14688263. doi:10.1074/jbc.M311891200. 
  • Komuro Y, Watanabe T, Kitayama J et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.". Hepatogastroenterology 50 (54): 1770–3. PMID 14696401. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Kaneider NC, Lindner J, Feistritzer C et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. PMID 15208267. doi:10.1096/fj.03-1050fje. 

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