Melanin-koncentrirajući hormonski receptor
Izgled
Melanin-koncentrirajući hormonski receptor 1 | |
---|---|
Identifikatori | |
Simbol | MCHR1 |
Alt. simboli | GPR24 |
Entrez | 2847 |
HUGO | 4479 |
OMIM | 601751 |
RefSeq | NM_005297 |
UniProt | Q99705 |
Drugi podaci | |
Lokus | Hromozom 22 q13.3 |
Melanin-koncentrirajući hormonski receptor 2 | |
---|---|
Identifikatori | |
Simbol | MCHR2 |
Alt. simboli | GPR145 |
Entrez | 84539 |
HUGO | 20867 |
OMIM | 606111 |
RefSeq | NM_032503 |
UniProt | Q969V1 |
Drugi podaci | |
Lokus | Hromozom 6 q16 |
Melanin-koncentrirajući hormonski receptori (MCHR) su nadavno bili karakterisani: MCH-R1 i MCH-R2. Ova dva receptora su aproksimativno 38% homologna.
- MCH-R1 je izražen kod svih sisara.
- MCH-R2 je nađen sam kod nekih primata i mesojeda, što obuhvata pse, feretki i ljude.
Antagonisti su potencijalno korisni za lečenje gojaznosti[1][2], strepnje i depresije.[3] Moguće je da će agonisti naći upotrebu u tretmanu osteoporoze.[4]
U toku su istraživanja za antagoniste oba MCH receptora, R1 i R2.[5][6]
- ↑ Handlon AL, Zhou H (2006). „Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity”. J. Med. Chem. 49 (14): 4017–22. DOI:10.1021/jm058239j. PMID 16821761.
- ↑ Luthin DR (2007). „Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists”. Life Sci. 81 (6): 423–40. DOI:10.1016/j.lfs.2007.05.029. PMID 17655875.
- ↑ Shimazaki T, Yoshimizu T, Chaki S (2006). „Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders”. CNS drugs 20 (10): 801–11. PMID 16999451.
- ↑ Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C (2004). „Osteoporosis in MCHR1-deficient mice”. Biochem. Biophys. Res. Commun. 318 (4): 964–9. DOI:10.1016/j.bbrc.2004.04.122. PMID 15147966.
- ↑ Saito Y, Maruyama K (2006). „Identification of melanin-concentrating hormone receptor and its impact on drug discovery”. J. Exp. Zoolog. Part a Comp. Exp. Biol. 305 (9): 761–8. DOI:10.1002/jez.a.311. PMID 16902961.
- ↑ McBriar MD (2006). „Recent advances in the discovery of melanin-concentrating hormone receptor antagonists”. Current opinion in drug discovery & development 9 (4): 496–508. PMID 16889232.
- „Melanin-Concentrating Hormone Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.