ATC-0175

ATC-0175
(IUPAC) ime
	N-[cis-4-([4-(dimetilamino)hinazolin-2-il]amino)cikloheksil]-3,4-difluorobenzamid
Klinički podaci
Identifikatori
ATC kod	?
ChemSpider	8109661
Hemijski podaci
Formula	C23H25F2N5O
Mol. masa	425,473
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C23H25F2N5O/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29) ; Key: FAIMGWSOSCFGRU-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

ATC-0175 je lek koji se koristi u naučnim istraživanjima. On je selektivni nepeptidni antagonist melanin-koncentrirajućeg hormonskog receptora MCH₁. U životinjskim studijama je pokazano da proizvodi anksiolitičke i antidepresivne efekte, bez sedativnih ili ataksičnih nuspojava.^[2]^[3]^[4]

Literatura[uredi - уреди | uredi izvor]

↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3. edit
↑ Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W (May 2005). "Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists". The Journal of Pharmacology and Experimental Therapeutics 313 (2): 831–9. PMID 15677346. doi:10.1124/jpet.104.081711.
↑ Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Sekiguchi Y (September 2005). "Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1". Bioorganic & Medicinal Chemistry Letters 15 (17): 3853–6. PMID 16002290. doi:10.1016/j.bmcl.2005.05.121.
↑ Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y (2005). "ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety". CNS Drug Reviews 11 (4): 341–52. PMID 16614734. doi:10.1111/j.1527-3458.2005.tb00052.x.

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