ATC-0175
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| N-[cis-4-([4-(dimetilamino)hinazolin-2-il]amino)cikloheksil]-3,4-difluorobenzamid | |||
| Klinički podaci | |||
| Identifikatori | |||
| ATC kod | ? | ||
| ChemSpider[1] | 8109661 | ||
| Hemijski podaci | |||
| Formula | C23H25F2N5O | ||
| Mol. masa | 425,473 | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
ATC-0175 je lek koji se koristi u naučnim istraživanjima. On je selektivni nepeptidni antagonist melanin-koncentrirajućeg hormonskog receptora MCH1. U životinjskim studijama je pokazano da proizvodi anksiolitičke i antidepresivne efekte, bez sedativnih ili ataksičnih nuspojava.[2][3][4]
Literatura[uredi | uredi kod]
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W (May 2005). „Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists”. The Journal of Pharmacology and Experimental Therapeutics 313 (2): 831–9. DOI:10.1124/jpet.104.081711. PMID 15677346.
- ↑ Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Sekiguchi Y (September 2005). „Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1”. Bioorganic & Medicinal Chemistry Letters 15 (17): 3853–6. DOI:10.1016/j.bmcl.2005.05.121. PMID 16002290.
- ↑ Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y (2005). „ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety”. CNS Drug Reviews 11 (4): 341–52. DOI:10.1111/j.1527-3458.2005.tb00052.x. PMID 16614734.
