Neurokinin A

Neurokinin A
Identifikacija
CAS registarski broj	86933-74-6
PubChem	55582
MeSH	Neurokinin+A
Svojstva
Molekulska formula	C50H80N14O14S
Molarna masa	1133.32
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

TAC1 tachykinin, precursor 1
	Struktura tahikiniskog peptida neurokinin A u presustvu micela.
Identifikatori
Simbol	TAC1
Alt. simboli	TAC2, NKNA
Entrez	6863
HUGO	11517
OMIM	162320
RefSeq	NM_013998
UniProt	P20366
Drugi podaci
Lokus	Hromozom 7 q21-q22

Neurokinin A (ranije poznat kao supstanca K) je član tahikininske familije neuropeptidnih neurotransmitera. On nastaje iz istog preprotahikinin A gena kao i neuropeptid supstanca P. On ima više uloga u telu čoveka i životinja. Jedan specifičan primer je posredovanje kontraktovanje debelog creva i bronhokonstrikcija kod pacova kroz ne-noradrenergički, ne-holinergički nervni sistem (ogranak vagalnog sistema). Neuropeptid K (koji se takođe naziva neurokinin K^[4]) i neuropeptid gama su N-terminalno duže verzije neurokinina A, proizvedene iz iste splajsne forme gena, koji su finalni peptidni produkti u istim tkivima.^[5]

Struktura

Struktura neurokinina A sisara je dobijena koristeći CD spectropolarimetriju i 2D protonsku NMR.^[1] Analiza je pokazala da u vodi, peptid poprima izduženu konformaciju dok u prisustvu micela (model sistema ćelijske membrane), alfa heliksna konformacija je indukovana u centralnom delu (Asp4-Met10).^[1]

Reference

↑ ^1,0 ^1,1 ^1,2 PDB 1N6T; Chandrashekar IR, Cowsik SM (December 2003). „Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles”. Biophys. J. 85 (6): 4002–11. DOI:10.1016/S0006-3495(03)74814-0. PMC 1303701. PMID 14645089.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
↑ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945

Literatura

Maggi C, Patacchini R, Rovero P, Giachetti A (1993). „Tachykinin receptors and tachykinin receptor antagonists”. J Auton Pharmacol 13 (1): 23–93. DOI:10.1111/j.1474-8673.1993.tb00396.x. PMID 8382703.
Regoli D, Boudon A, Fauchére J (1994). „Receptors and antagonists for substance P and related peptides”. Pharmacol Rev 46 (4): 551–99. PMID 7534932.

Spoljašnje veze

Portal Hemija

[pmid14645089-1] 1,0 ^1,1 ^1,2 PDB 1N6T; Chandrashekar IR, Cowsik SM (December 2003). „Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles”. Biophys. J. 85 (6): 4002–11. DOI:10.1016/S0006-3495(03)74814-0. PMC 1303701. PMID 14645089.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487

[Carter-5] Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945

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Neurokinin A

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Neurokinin A

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