Fisalaemin

Fisalaemin
Identifikacija
CAS registarski broj	2507-24-6
PubChem	17268
MeSH	Physalaemin
ChEMBL	CHEMBL415235
Jmol-3D slike	Slika 1
SMILES
	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C3CCCN3C(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C4CCC(=O)N4
InChI
	InChI=1S/C58H84N14O16S/c1-31(2)25-39(54(84)66-36(49(61)79)21-24-89-4)65-47(76)30-62-51(81)40(27-34-15-17-35(73)18-16-34)68-55(85)41(26-33-11-6-5-7-12-33)69-53(83)37(13-8-9-22-59)67-56(86)42(28-45(60)74)70-57(87)44-14-10-23-72(44)58(88)43(29-48(77)78)71-50(80)32(3)63-52(82)38-19-20-46(75)64-38/h5-7,11-12,15-18,31-32,36-44,73H,8-10,13-14,19-30,59H2,1-4H3,(H2,60,74)(H2,61,79)(H,62,81)(H,63,82)(H,64,75)(H,65,76)(H,66,84)(H,67,86)(H,68,85)(H,69,83)(H,70,87)(H,71,80)(H,77,78) ; Kod: SHSUJLMLURFKID-UHFFFAOYSA-N
Svojstva
Molekulska formula	C58H84N14O16S
Molarna masa	1265.44 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Fisalaemin je tahikininski peptid dobijen iz Physalaemus žaba. On je blisko srodan sa supstancom P. Njegova struktura je prvi put utvrđena 1964.^[4]^[5]

Poput svih tahikinina, fisalaemin povećava salivaciju, i deluje kao potentan vazodilatator sa hipotenzivnim efektima.^[6]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). „Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus”. Experientia 20 (9): 489–90. DOI:10.1007/BF02154064. PMID 5857249.
↑ Anastasi A, Erspamer V, Cei JM (1964). „Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus”. Arch Biochem Biophys 108 (2): 341–8. DOI:10.1016/0003-9861(64)90395-9. PMID 14240587.
↑ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). „The tachykinin peptide family”. Pharmacol Rev 54 (2): 285–322. DOI:10.1124/pr.54.2.285. PMID 12037144. Free full text Arhivirano 2009-06-06 na Wayback Machine-u

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). „Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus”. Experientia 20 (9): 489–90. DOI:10.1007/BF02154064. PMID 5857249.

[5] Anastasi A, Erspamer V, Cei JM (1964). „Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus”. Arch Biochem Biophys 108 (2): 341–8. DOI:10.1016/0003-9861(64)90395-9. PMID 14240587.

[6] Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). „The tachykinin peptide family”. Pharmacol Rev 54 (2): 285–322. DOI:10.1124/pr.54.2.285. PMID 12037144. Free full text Arhivirano 2009-06-06 na Wayback Machine-u

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