Metabotropni glutamatni receptor 7

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Metabotropni glutamatni receptor 7

PDB prikaz baziran na 2e4z.
Dostupne strukture
3MQ4
Identifikatori
SimboliGRM7; GLUR7; GPRC1G; MGLU7; MGLUR7
Vanjski IDOMIM604101 MGI1351344 HomoloGene20233 IUPHAR: mGlu7 GeneCards: GRM7 Gene
Pregled RNK izražavanja
PBB GE GRM7 217008 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez2917108073
EnsemblENSG00000196277ENSMUSG00000056755
UniProtQ14831Q68ED2
RefSeq (mRNA)NM_000844.3NM_177328.3
RefSeq (protein)NP_000835.1NP_796302.2
Lokacija (UCSC)Chr 3:
6.81 - 7.78 Mb
Chr 6:
110.6 - 111.52 Mb
PubMed pretraga[1][2]

Metabotropni glutamatni receptor 7 je protein koji je kod ljudi kodiran GRM7 genom.[1][2][3]

Funkcija[uredi - уреди | uredi izvor]

L-glutamat je jedan od glavnih ekscitatornih neurotransmitera u centralnom nervnom sistemu. On aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalih moždanih funkcija i njena perturbacija se javlja kod mnogih neuropatoloških oboljenja. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvenci, mehanizama prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ti receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok grupa III obuhvata GRM4, GRM6, GRM7 i GRM8. Receptori grupe II i III su povezani inhibicijom kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste.[3]

Ligandi[uredi - уреди | uredi izvor]

Agonisti[uredi - уреди | uredi izvor]

Antagonisti[uredi - уреди | uredi izvor]

  • MMPIP: alosterni antagonist/inverzni agonist[7]

Interakcije[uredi - уреди | uredi izvor]

Metabotropni glutamatni receptor 7 formira interakcije sa PICK1.[8]

Reference[uredi - уреди | uredi izvor]

  1. Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (February 1994). "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction". J Biol Chem 269 (2): 1231–6. PMID 8288585. 
  2. Makoff A, Pilling C, Harrington K, Emson P (January 1997). "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS". Brain Res Mol Brain Res 40 (1): 165–70. PMID 8840028. doi:10.1016/0169-328X(96)00110-6. 
  3. 3,0 3,1 "Entrez Gene: GRM7 glutamate receptor, metabotropic 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917. 
  4. Li X, Gardner EL, Xi ZX (2008). "The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats". Neuropharmacology 54 (3): 542–51. PMC 2410088. PMID 18155073. doi:10.1016/j.neuropharm.2007.11.005. 
  5. 5,0 5,1 Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). "Activation of the mGlu7 receptor elicits antidepressant-like effects in mice". Psychopharmacology (Berl.) 194 (4): 555–62. PMID 17622518. doi:10.1007/s00213-007-0856-2. 
  6. Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). "mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082". Neuropharmacology 52 (1): 108–17. PMID 16914173. doi:10.1016/j.neuropharm.2006.07.020. 
  7. Suzuki G, Tsukamoto N, Fushiki H et al. (2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". J. Pharmacol. Exp. Ther. 323 (1): 147–56. PMID 17609420. doi:10.1124/jpet.107.124701. 
  8. Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. (UNITED STATES) 20 (19): 7252–7. PMID 11007882. 

Literatura[uredi - уреди | uredi izvor]

  • Scherer SW; Duvoisin RM; Kuhn R et al. (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics 31 (2): 230–3. PMID 8824806. doi:10.1006/geno.1996.0036. 
  • Flor PJ; Van Der Putten H; Rüegg D et al. (1997). "A novel splice variant of a metabotropic glutamate receptor, human mGluR7b". Neuropharmacology 36 (2): 153–9. PMID 9144652. doi:10.1016/S0028-3908(96)00176-1. 
  • Wu S; Wright RA; Rockey PK et al. (1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Res. Mol. Brain Res. 53 (1–2): 88–97. PMID 9473604. doi:10.1016/S0169-328X(97)00277-5. 
  • Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). "A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7". J. Biol. Chem. 274 (39): 27573–7. PMID 10488094. doi:10.1074/jbc.274.39.27573. 
  • O'Connor V; El Far O; Bofill-Cardona E et al. (1999). "Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling". Science 286 (5442): 1180–4. PMID 10550060. doi:10.1126/science.286.5442.1180. 
  • Barbon A, Ferraboli S, Barlati S (2000). "Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 288. PMID 10828612. doi:10.1159/000015541. 
  • Dev KK; Nakajima Y; Kitano J et al. (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882. 
  • Bolonna AA; Kerwin RW; Munro J et al. (2001). "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia". Schizophr. Res. 47 (1): 99–103. PMID 11163549. doi:10.1016/S0920-9964(99)00235-2. 
  • Hirbec H; Perestenko O; Nishimune A et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. PMID 11891216. doi:10.1074/jbc.C200112200. 
  • Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X. 
  • Saugstad JA; Yang S; Pohl J et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. PMC 2925652. PMID 11953448. doi:10.1046/j.0022-3042.2002.00778.x. 
  • Schulz HL, Stohr H, Weber BH (2002). "Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)". Neurosci. Lett. 326 (1): 37–40. PMID 12052533. doi:10.1016/S0304-3940(02)00306-3. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Kobayashi Y; Akiyoshi J; Kanehisa M et al. (2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatr. Genet. 17 (1): 9. PMID 17167337. doi:10.1097/YPG.0b013e32801118bc. 

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