Receptor slobodnih masnih kiselina 1

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Receptor slobodnih masnih kiselina 1
Identifikatori
SimboliFFAR1; FFA1R; GPCR40; GPR40
Vanjski IDOMIM603820 MGI2684079 HomoloGene3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Ortolozi
VrstaČovekMiš
Entrez2864233081
EnsemblENSG00000126266ENSMUSG00000044453
UniProtO14842Q76JU9
RefSeq (mRNA)NM_005303.2NM_194057.2
RefSeq (protein)NP_005294.1NP_918946.2
Lokacija (UCSC)Chr 19:
35.84 - 35.84 Mb
Chr 7:
31.65 - 31.65 Mb
PubMed pretraga[1][2]

Receptor slobodnih masnih kiselina 1 (FFA1) je G protein spregnuti receptor kodiran ljudskim genom FFAR1.[1] On je u znatnoj meri izražen u ćelijama pankreasa, a u manjoj meri u materici i mozgu.[2]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors.". DNA Cell Biol. 24 (1): 54–61. PMID 15684720. doi:10.1089/dna.2005.24.54. 
  • Sawzdargo M, George SR, Nguyen T et al. (1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.". Biochem. Biophys. Res. Commun. 239 (2): 543–7. PMID 9344866. doi:10.1006/bbrc.1997.7513. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Briscoe CP, Tadayyon M, Andrews JL et al. (2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.". J. Biol. Chem. 278 (13): 11303–11. PMID 12496284. doi:10.1074/jbc.M211495200. 
  • Kotarsky K, Nilsson NE, Flodgren E et al. (2003). "A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.". Biochem. Biophys. Res. Commun. 301 (2): 406–10. PMID 12565875. doi:10.1016/S0006-291X(02)03064-4. 
  • Itoh Y, Kawamata Y, Harada M et al. (2003). "Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.". Nature 422 (6928): 173–6. PMID 12629551. doi:10.1038/nature01478. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
  • Hardy S, St-Onge GG, Joly E et al. (2005). "Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.". J. Biol. Chem. 280 (14): 13285–91. PMID 15695516. doi:10.1074/jbc.M410922200. 
  • Ogawa T, Hirose H, Miyashita K et al. (2005). "GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.". Metab. Clin. Exp. 54 (3): 296–9. PMID 15736105. doi:10.1016/j.metabol.2004.09.008. 
  • Tomita T, Masuzaki H, Noguchi M et al. (2006). "GPR40 gene expression in human pancreas and insulinoma.". Biochem. Biophys. Res. Commun. 338 (4): 1788–90. PMID 16289108. doi:10.1016/j.bbrc.2005.10.161. 
  • Tomita T, Masuzaki H, Iwakura H et al. (2006). "Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.". Diabetologia 49 (5): 962–8. PMID 16525841. doi:10.1007/s00125-006-0193-8. 
  • Stoddart LA, Brown AJ, Milligan G (2007). "Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.". Mol. Pharmacol. 71 (4): 994–1005. PMID 17200419. doi:10.1124/mol.106.031534. 
  • Bartoov-Shifman R, Ridner G, Bahar K et al. (2007). "Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.". J. Biol. Chem. 282 (32): 23561–71. PMID 17525159. doi:10.1074/jbc.M702115200. 
  • Sum CS, Tikhonova IG, Neumann S et al. (2007). "Identification of residues important for agonist recognition and activation in GPR40.". J. Biol. Chem. 282 (40): 29248–55. PMID 17699519. doi:10.1074/jbc.M705077200. 

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