Melatoninski receptor 1A

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
edit
Melatoninski receptor 1A
Identifikatori
SimboliMTNR1A; MEL-1A-R; MT1
Vanjski IDOMIM600665 MGI102967 HomoloGene21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
Pregled RNK izražavanja
PBB GE MTNR1A 221369 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez454317773
EnsemblENSG00000168412ENSMUSG00000054764
UniProtP48039Q61184
RefSeq (mRNA)NM_005958.3NM_008639.2
RefSeq (protein)NP_005949.1NP_032665.1
Lokacija (UCSC)Chr 4:
187.35 - 187.48 Mb
Chr 8:
46.15 - 46.17 Mb
PubMed pretraga[1][2]

Melatoninski receptor tip 1A je protein koji je kod ljudi kodiran MTNR1A genom.[1][2]

MT1 protein je jedan od dva receptora sa visokim afinitetom za melatonin, koji je primarni hormon epifize. Ovaj receptor je G protein spregnuti 7-transmembranski receptor koji je odgovoran za dejstvo melatonina na sisarski cirkadijanski ritam i reproduktivne promene na koje utiče dužina dana. Ovaj receptor je integralni membranski protein koji je lociran u dva specifična moždana regiona. Hipotalamusno suprahiazmatično jedro učestvuju u cirkadijanskom ritmu, dok je hipofizni pars tuberalis odgovoran za reproduktivne efekte melatonina.[2]

Reference[uredi - уреди | uredi izvor]

  1. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (Nov 1995). "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)". Genomics 27 (2): 355–7. PMID 7558006. doi:10.1006/geno.1995.1056.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: MTNR1A melatonin receptor 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4543. 

Literatura[uredi - уреди | uredi izvor]

  • Brzezinski A; Brzezinski, Amnon (1997). "Melatonin in humans". N. Engl. J. Med. 336 (3): 186–95. PMID 8988899. doi:10.1056/NEJM199701163360306. 
  • Khan AU, Olson DL (1975). "Physical therapy and exercise-induced bronchospasm". Physical therapy 55 (8): 878–81. PMID 1144527. 
  • Reppert SM, Weaver DR, Ebisawa T (1994). "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses". Neuron 13 (5): 1177–85. PMID 7946354. doi:10.1016/0896-6273(94)90055-8. 
  • Witt-Enderby PA, Dubocovich ML (1996). "Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells". Mol. Pharmacol. 50 (1): 166–74. PMID 8700109. 
  • Witt-Enderby PA, Masana MI, Dubocovich ML (1998). "Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor". Endocrinology 139 (7): 3064–71. PMID 9645677. doi:10.1210/en.139.7.3064. 
  • Ebisawa T; Kajimura N; Uchiyama M et al. (1999). "Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders". Biochem. Biophys. Res. Commun. 262 (3): 832–7. PMID 10471411. doi:10.1006/bbrc.1999.1308. 
  • Brydon L; Roka F; Petit L et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. PMID 10598579. doi:10.1210/me.13.12.2025. 
  • Niles LP; Wang J; Shen L et al. (2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1–2): 107–10. PMID 10612428. doi:10.1016/S0303-7207(99)00135-5. 
  • Song CK, Bartness TJ (2001). "CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity". Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666–72. PMID 11448873. 
  • Roy D; Angelini NL; Fujieda H et al. (2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology 142 (11): 4711–20. PMID 11606436. doi:10.1210/en.142.11.4711. 
  • Savaskan E; Olivieri G; Meier F et al. (2002). "Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients". J. Pineal Res. 32 (1): 59–62. PMID 11841602. doi:10.1034/j.1600-079x.2002.00841.x. 
  • Savaskan E; Wirz-Justice A; Olivieri G et al. (2002). "Distribution of melatonin MT1 receptor immunoreactivity in human retina". J. Histochem. Cytochem. 50 (4): 519–26. PMID 11897804. 
  • Ayoub MA; Couturier C; Lucas-Meunier E et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". J. Biol. Chem. 277 (24): 21522–8. PMID 11940583. doi:10.1074/jbc.M200729200. 
  • Yuan L; Collins AR; Dai J et al. (2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Mol. Cell. Endocrinol. 192 (1–2): 147–56. PMID 12088876. doi:10.1016/S0303-7207(02)00029-1. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Slominski A; Pisarchik A; Zbytek B et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53. PMID 12767050. doi:10.1002/jcp.10287. 
  • Morcuende JA; Minhas R; Dolan L et al. (2004). "Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis". Spine 28 (17): 2025–8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49. 
  • Aust S; Thalhammer T; Humpeler S et al. (2004). "The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia". J. Pineal Res. 36 (1): 43–8. PMID 14675129. doi:10.1046/j.1600-079X.2003.00095.x. 

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]